Table 1.
Characteristics of 432 hepatitis B virus-infected patients in different fibrosis stages diagnosed by liver biopsy (mean ± SD)
| Variables |
Fibrosis stage |
P value | |||
| F0-F1 | F2 | F3 | F4 | ||
| Cases, n | 95 | 126 | 103 | 108 | / |
| Male, n (%) | 62 (65.26) | 88 (69.84) | 82 (79.61) | 89 (82.41) | / |
| Age (yr) | 37.91 ± 10.71 | 36.52 ± 11.11 | 41.71 ± 10.01 | 46.63 ± 9.95 | < 0.001c |
| HBV DNA (IU/mL) | 1.26 × 108 ± 3.64 ×108 | 1.33 × 108 ± 4.01 × 108 | 6.39 × 107 ± 1.62 × 108 | 5.63 × 107 ± 1.56 × 108 | 0.229 |
| AFP (ng/mL) | 3.20 ± 3.01 | 19.37 ± 100.27 | 12.56 ± 23.25 | 40.98 ± 160.29 | 0.118 |
| ALT (IU/L) | 42.58 ± 61.49 | 125.21 ± 211.29 | 263.82 ± 421.57 | 115.84 ± 165.90 | < 0.001c |
| AST (IU/L) | 30.45 ± 39.36 | 85.65 ± 171.17 | 185.61 ± 292.67 | 92.18 ± 127.81 | < 0.001c |
| GGT (IU/L) | 31.59 ± 26.74 | 42.10 ± 50.37 | 78.13 ± 107.06 | 64.47 ± 68.93 | < 0.001c |
| ALP (IU/L) | 75.63 ± 21.27 | 81.56 ± 31.47 | 109.30 ± 120.10 | 103.82 ± 41.55 | 0.002b |
| PLT (109/L) | 206.91 ± 51.14 | 198.36 ± 55.72 | 185.36 ± 58.29 | 134.95 ± 46.41 | < 0.001c |
| Total bilirubin (μmol/L) | 13.09 ± 5.30 | 18.34 ± 16.99 | 29.93 ± 31.44 | 22.67 ± 12.60 | < 0.001c |
| Indirect bilirubin (μmol /L) | 7.78 ± 4.31 | 8.40 ± 9.40 | 13.46 ± 17.05 | 10.01 ± 7.94 | 0.003b |
| Total protein (g/L) | 73.46 ± 4.78 | 73.61 ± 10.53 | 72.48 ± 11.14 | 74.44 ± 7.66 | 0.635 |
| Albumin (g/L) | 45.80 ± 3.30 | 45.44 ± 4.40 | 45.33 ± 6.51 | 44.39 ± 5.39 | 0.320 |
b
P < 0.01.
c
P < 0.001. Reference values: AST: 8-38 IU/L; ALT: 4-44 IU/L; GGT: 8-64 IU/L; ALP: 40-129 IU/L; AFP: 0-20 μg/L; PLT: 100-300 × 109/L; TB: 5.1-18.8 μmol/L; IB: 0-12 μmol/L; TP: 60-87 g/L; ALB: 34-55 g/L. HBV: Hepatitis B virus; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; GGT: γ-glutamyl-transpeptidase; ALP: Alkaline phosphatase.