Table 2.
Prognostic factors for overall survival based on univariate analysis of the matched data
|
PA-TACE |
Surgery alone |
|||||
| Characteristic | Hazard ratio | 95%CI | P value | Hazard ratio | 95%CI | P value |
| Age (yr) | 0.043 | 0.166 | ||||
| < 65 | Reference | Reference | ||||
| ≥ 65 | 0.300 | 0.093-0.963 | 0.043 | 1.490 | 0.848-2.619 | 0.166 |
| Gender | 0.578 | 0.001 | ||||
| Male | Reference | Reference | ||||
| Female | 0.785 | 0.334-1.844 | 0.578 | 0.382 | 0.217-0674 | 0.001 |
| BMI | 0.187 | 0.121 | ||||
| < 23 | Reference | Reference | ||||
| 23-25 | 0.497 | 0.233-1.060 | 0.070 | 0.859 | 0.525-1.407 | 0.546 |
| ≥ 25 | 0.912 | 0.476-1.747 | 0.781 | 0.517 | 0.275-0.971 | 0.040 |
| BCLC stage | 0.015 | 0.045 | ||||
| 0 | Reference | Reference | ||||
| A | 4.287 | 1.333-13.785 | 0.015 | 1.839 | 1.014-3.403 | 0.045 |
| HBV | 0.693 | 0.038 | ||||
| Negative | Reference | Reference | ||||
| Positive | 1.205 | 0.478-3.038 | 0.693 | 2.414 | 1.049-5.553 | 0.038 |
| HCV | 0.367 | 0.645 | ||||
| Negative | Reference | Reference | ||||
| Positive | - | - | 0 | 0.000-NA | 0.963 | |
| Unknown | 0.047 | 0-36.104 | 0.367 | 0.390 | 0.054-2.804 | 0.350 |
| Cirrhosis | 0.166 | 0.129 | ||||
| No | Reference | Reference | ||||
| Yes | 1.516 | 0.841-2.730 | 0.166 | 1.440 | 0.899-2.307 | 0.129 |
| Family history | 0.936 | 0.543 | ||||
| No | Reference | Reference | ||||
| Yes | 0.966 | 0.411-2.269 | 0.936 | 0.806 | 0.402-1.615 | 0.543 |
| MVI | 0.005 | 0.439 | ||||
| No | Reference | Reference | ||||
| Yes | 2.557 | 1.332-4.910 | 0.005 | 1.275 | 0.689-2.359 | 0.439 |
| AFP (ng/mL) | 0.429 | 0.416 | ||||
| ≤ 200 | Reference | Reference | ||||
| > 200 | 1.255 | 0.715-2.203 | 0.429 | 1.203 | 0.771-1.878 | 0.416 |
| ALBI grade | 0.085 | < 0.001 | ||||
| 1 | Reference | Reference | ||||
| 2 | 1.637 | 0.934-2.871 | 0.085 | 2.303 | 1.466-3.620 | < 0.001 |
| 3 | - | - | - | - | - | - |
| NLR | 0.962 | 0.578 | ||||
| ≤ Median | Reference | Reference | ||||
| > Median | 0.986 | 0.563-1729 | 0.962 | 0.881 | 0.564-1.376 | 0.578 |
| Ferritin (ng/mL) | 0.056 | 0.323 | ||||
| ≤ 400 | Reference | Reference | ||||
| > 400 | 1.731 | 0.986-3.040 | 0.056 | 1.447 | 0.695-3.015 | 0.323 |
| FHR | 0.001 | < 0.001 | ||||
| ≤ Median | Reference | Reference | ||||
| > Median | 2.830 | 1.541-5.198 | 0.001 | 4.084 | 2.452-6.802 | < 0.001 |
| CRP (mg/L) | 0.670 | 0.875 | ||||
| ≤ 5 | Reference | Reference | ||||
| > 5 | 0.864 | 0.441-1.691 | 0.670 | 1.043 | 0.616-1.767 | 0.875 |
| Times | 0.193 | - | ||||
| 1 | Reference | - | - | |||
| 2 | 0.661 | 0.319-1.370 | 0.266 | - | - | |
| 3 | 2.171 | 0.668-7.059 | 0.197 | - | - | |
PA-TACE: Postoperative adjuvant transcatheter arterial chemoembolization; BMI: Body mass index; BCLC: Barcelona Clinic Liver Cancer system; HBV: Hepatitis B virus; HCV: Hepatitis C virus; MVI: Microscopic vascular invasion; AFP: Alpha fetoprotein; ALBI: Albumin-bilirubin; NLR: Neutrophil-to-lymphocyte ratio; FHR: Ferritin-to-hemoglobin ratio; CRP: C-reactive protein; NA: Not available.