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TRIM58 silencing promoted lactate production and glucose transport activity in human OS cells. (a) The lactate production was increased in siTRIM58-transfected cells. ∗∗∗p < 0.001 vs. siNC. (b) The production of 2-NBDG was increased in siTRIM58-transfected cells. ∗∗p < 0.01 vs. siNC. (c) The protein content of PKM2 and p-PKM2 was upregulated in siTRIM58-transfected cells. ∗∗∗p < 0.001 vs. siNC.
