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. 2020 Mar 7;2020:8450606. doi: 10.1155/2020/8450606

Figure 7.

Figure 7

TRIM58 interacted with PKM2 and enhanced its polyubiquitination in OS cells. (a, b) The relative protein contents of PKM2 and p-PKM2 were inhibited by MG132 in oeTRIM58-transfected cells. ∗∗∗p < 0.001 vs. DMSO + oeNC. ###p < 0.001 vs. DMSO + oeTRIM58. (c) Co-IP assay was performed to examine the interaction between TRIM58 and PKM2 in OS cells. (d) Overexpression of TRIM58 enhanced the polyubiquitination of PKM2 in OS cells. (e) PKM2 overexpression promoted the proliferation of oeTRIM58-transfected cells. ∗∗p < 0.01 vs. oeNC. ∗∗∗p < 0.001 vs. oeNC; !!p < 0.01 vs. oeTRIM58.