Figure 3.

miR-155-5p promotes oxalate- and COM-induced oxidative stress injury in HK-2 cells. (a–d) miR-155-5p inhibitor treatment significantly decreased ROS generation, LDH release, cellular MDA levels, and H₂O₂ concentration in HK-2 cells incubated with oxalate. (e–h) miR-155-5p inhibitor treatment significantly decreased ROS generation, LDH release, cellular MDA levels, and H₂O₂ concentration in HK-2 cells incubated with COM. ^∗P < 0.05 and ^∗∗P < 0.01 vs. NC group; ^△P < 0.05 vs. oxalate or COM group and miR-155-5p inhibitor group.