Table 1.
Baseline Patient Demographics and Clinical Characteristics
| Characteristic | Patients with MDD (n=986) |
|---|---|
| Age (years), mean (SD) | 35.9 (12.0) |
| Female sex, % (n) | 68.5 (675) |
| Region in China, % (n) | |
| North | 56.9 (561) |
| South | 6.8 (67) |
| East | 17.5 (173) |
| West | 18.8 (185) |
| Residential area, % (n) | |
| Urban | 82.2 (810) |
| Rural | 17.8 (176) |
| Employed, % (n) | 57.0 (562) |
| Educational level, % (n) | |
| Middle school or lower | 23.3 (230) |
| High school or junior college | 31.7 (313) |
| University or postgraduate | 44.9 (443) |
| Clinical history, % (n) | |
| Previous episode | 39.2 (387) |
| Switching antidepressant at baseline | 20.6 (203) |
| Baseline assessment scores, mean (SD) | |
| HAM-D17 total score | 23.2 (4.4) |
| PHQ-9 total score | 16.7 (5.8) |
| DSST | 50.7 (16.8) |
| PDQ-D total score | 33.6 (16.3) |
| EQ-5D utility index | 0.74 (0.14) |
| SDS absenteeism (work days lost) | 2.0 (2.5) |
| SDS presenteeism (work days underproductive) | 3.7 (2.5) |
| WPAI absenteeism (%) | 26.3 (35.7) |
| WPAI presenteeism (%) | 54.5 (26.8) |
| PDQ-D quartile, % (n) | |
| 0–20 | 24.0 (231) |
| 21–32 | 25.7 (247) |
| 33–44 | 24.9 (239) |
| 45–80 | 25.4 (244) |
| Missing (n) | 25 |
| DSST subgroup, % (n) | |
| Within norm | 45.4 (445) |
| ⅓–⅔ SD below norm | 13.3 (130) |
| ⅔–1 SD below norm | 10.9 (107) |
| ≥1 SD below norm | 30.5 (299) |
| Missing (n) | 5 |
| DSST quartile, % (n) | |
| 0–37 | 23.8 (233) |
| 38–51 | 25.0 (245) |
| 52–62 | 25.9 (254) |
| 63–133 | 25.4 (249) |
| Missing (n) | 5 |
Abbreviations: DSST, Digit Symbol Substitution Test; EQ-5D, EuroQol 5-Dimensions Questionnaire; HAM-D17, 17-item Hamilton Depression Rating Scale; MDD, major depressive disorder; PDQ-D, 20-item Perceived Deficits Questionnaire-Depression; PHQ-9, 9-item Patient Health Questionnaire; SD, standard deviation; SDS, Sheehan Disability Scale; WPAI, Work Productivity and Activity Impairment.