Table 2.
Multiple comparisons of DTI measures of ROI (dependent variables) in MCI, AD, and control groups
| CN Mean (SD) | MCI Mean (SD) | AD Mean (SD) | p | |
| AxD | ||||
| Left frontal | 1.21 (0.12) | 1.24 (0.08) | 1.29 (0.12) | 0.074 |
| Left insula | 1.21 (0.17)* | 1.23 (0.11) | 1.31 (0.11) | 0.026 |
| Left limbic | 1.37 (0.21)* | 1.52 (0.33)* | 1.75 (0.32) | <0.001 |
| Left occipital | 1.21 (0.16) | 1.26 (0.16) | 1.33 (0.19) | 0.057 |
| Left parietal | 1.25 (0.18) | 1.26 (0.11) | 1.26 (0.11) | 0.054 |
| Left temporal | 1.27 (0.14)* | 1.35 (0.17)* | 1.35 (0.17) | <0.001 |
| Right frontal | 1.22 (0.12) | 1.26 (0.09) | 1.26 (0.09) | 0.051 |
| Right insula | 1.26 (0.21)* | 1.31 (0.15) | 1.31 (0.15) | 0.007 |
| Right limbic | 1.33 (0.19)* | 1.48 (0.35) | 1.48 (0.35) | 0.001 |
| Right occipital | 1.19 (0.14) | 1.19 (0.11) | 1.19 (0.11) | 0.19 |
| Right parietal | 1.27 (0.19) | 1.28 (0.13) | 1.28 (0.13) | 0.072 |
| Right temporal | 1.24 (0.16)* | 1.31 (0.18)* | 1.31 (0.18) | <0.001 |
| MD | ||||
| Left frontal | 0.96 (0.11) | 0.98 (0.07) | 1.03 (0.11) | 0.085 |
| Left insula | 0.92 (0.11)* | 0.94 (0.08) | 0.97 (0.08) | 0.038 |
| Left limbic | 1.04 (0.16)* | 1.19 (0.31)* | 1.36 (0.29) | <0.001 |
| Left occipital | 0.96 (0.13)* | 1.01 (0.14) | 1.09 (0.17) | 0.013 |
| Left parietal | 0.99 (0.16) | 1.01 (0.09) | 1.08 (0.14) | 0.061 |
| Left temporal | 0.98 (0.11)* | 1.06 (0.14)* | 1.29 (0.18) | <0.001 |
| Right frontal | 0.95 (0.11)* | 1.01 (0.07) | 1.03 (0.11) | 0.024 |
| Right insula | 0.97 (0.14)* | 1.02 (0.12) | 1.12 (0.16) | 0.002 |
| Right limbic | 1.01 (0.15)* | 1.15 (0.33) | 1.31 (0.29) | 0.001 |
| Right occipital | 0.95 (0.12) | 0.96 (0.09) | 1.02 (0.12) | 0.018 |
| Right parietal | 0.99 (0.18)* | 1.02 (0.11) | 1.11 (0.14) | 0.043 |
| Right temporal | 0.96 (0.14)* | 1.03 (0.15)* | 1.23 (0.22) | <0.001 |
| RD | ||||
| Left frontal | 0.84 (0.11) | 0.86 (0.11) | 0.89 (0.11) | 0.11 |
| Left insula | 0.81 (0.11) | 0.79 (0.11) | 0.81 (0.08) | 0.97 |
| Left limbic | 0.91 (0.16)* | 1.02 (0.16) | 1.17 (0.08) | 0.003 |
| Left occipital | 0.87 (0.14) | 0.86 (0.13) | 0.97 (0.16) | 0.051 |
| Left parietal | 0.88 (0.15) | 0.87 (0.16) | 0.94 (0.13) | 0.13 |
| Left temporal | 0.86 (0.11)* | 0.92 (0.11)* | 1.13 (0.17) | <0.001 |
| Right frontal | 0.84 (0.11) | 0.87 (0.11) | 0.91 (0.09) | 0.074 |
| Right insula | 0.85 (0.14)* | 0.88 (0.14) | 0.96 (0.16) | 0.026 |
| Right limbic | 0.86 (0.14)* | 0.97 (0.15) | 1.12 (0.29) | 0.005 |
| Right occipital | 0.85 (0.12) | 0.85 (0.12) | 0.91 (0.11) | 0.21 |
| Right parietal | 0.89 (0.16) | 0.89 (0.18) | 0.97 (0.14) | 0.14 |
| Right temporal | 0.84 (0.13)* | 0.89 (0.14)* | 1.08 (0.21) | <0.001 |
| FA | ||||
| Left frontal | 0.27 (0.02) | 0.27 (0.01) | 0.27 (0.02) | 0.76 |
| Left insula | 0.30 (0.05) | 0.29 (0.04) | 0.30 (0.05) | 0.08 |
| Left limbic | 0.28 (0.05) | 0.27 (0.05) | 0.28 (0.05) | 0.32 |
| Left occipital | 0.24 (0.02) | 0.24 (0.02) | 0.24 (0.02) | 0.41 |
| Left parietal | 0.26 (0.02) | 0.27 (0.01) | 0.26 (0.02) | 0.57 |
| Left temporal | 0.27 (0.02) | 0.26 (0.01) | 0.27 (0.02) | 0.21 |
| Right frontal | 0.28 (0.02) | 0.27 (0.01) | 0.28 (0.02) | 0.31 |
| Right insula | 0.28 (0.03) | 0.26 (0.03) | 0.28 (0.03) | 0.26 |
| Right limbic | 0.30 (0.04) | 0.29 (0.03) | 0.30 (0.04) | 0.69 |
| Right occipital | 0.24 (0.02) | 0.24 (0.02) | 0.24 (0.02) | 0.78 |
| Right parietal | 0.26 (0.02) | 0.26 (0.01) | 0.26 (0.02) | 0.64 |
| Right temporal | 0.27 (0.02) | 0.26 (0.01) | 0.27 (0.02) | 0.09 |
Multiple comparisons of DTI measures of ROI in MCI, AD, and control groups. NC, normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; AxD, axial diffusion; MD, mean diffusion; RD, radial diffusion; FA, fractional anisotropy. p < 0.05 was considered statistically significant and bold font indicates statistical significance. Post-hoc multiple comparison analysis: *statistically significant versus AD; #statistically significant versus MCI.