Table 1.
Secondary stroke prevention at different time points in patients with and without dementia and first ischemic stroke
| Prior to Stroke | Initiation Planned at Discharge | 1-Year Post-Stroke | 2-Years Post-Stroke | 3-Years Post-Stroke | |||||||||||
| D | C | p | D | C | p | D | C | p | D | C | p | D | C | p | |
| n = 1410 | n = 7150 | n = 1241 | n = 6319 | n = 889 | n = 5224 | n = 651 | n = 4187 | n = 352 | n = 2619 | ||||||
| Age, mean (SD) | 83 (7) | 82 (7) | 0.043 | 82 (7) | 82 (7) | 0.025 | 82 (7) | 82 (7) | 0.108 | 83 (8) | 82 (7) | 0.043 | 83 (7) | 82 (7) | 0.025 |
| Female sex | 795 (56.4) | 4054 (56.7) | 0.827 | 693 (55.8) | 3543 (56.1) | 0.883 | 501 (56.4) | 2859 (54.7) | 0.367 | 300 (57.4) | 1858 (55.3) | 0.377 | 157 (58.8) | 1063 (54.4) | 0.173 |
| Antiplatelets | 674 (47.8) | 2641 (36.9) | <0.001 | 952 (77.5) | 4604 (73.1) | 0.001 | 621 (69.9) | 3039 (58.2) | <0.001 | 351 (67.1) | 1995 (59.4) | 0.001 | 173 (64.8) | 1106 (56.6) | 0.011 |
| in AF | 272 (56.9) | 874 (44.4) | <0.001 | 244 (56.5) | 788 (37.5) | <0.001 | 133 (49.3) | 376 (23.3) | <0.001 | 65 (44.8) | 234 (24.3) | <0.001 | 35 (52.2) | 119 (23.4) | <0.001 |
| in non-AF | 402 (43.1) | 1767 (34.1) | <0.001 | 706 (88.9) | 3794 (90.9) | 0.073 | 482 (78.8) | 2646 (73.9) | 0.011 | 283 (75.5) | 1750 (73.7) | 0.457 | 138 (69.0) | 978 (68.3) | 0.841 |
| Anticoagulants in AF | 54 (11.3) | 359 (18.2) | <0.001 | 132 (30.7) | 1188 (56.5) | <0.001 | 74 (27.4) | 762 (47.2) | <0.001 | 28 (19.3) | 429 (44.6) | <0.001 | 14 (20.9) | 228 (44.8) | <0.001 |
| BPLM | 930 (66.0) | 4792 (67.0) | 0.438 | 897 (73.1) | 5148 (81.8) | <0.001 | 612 (68.8) | 4035 (77.2) | <0.001 | 354 (67.7) | 2616 (77.9) | <0.001 | 173 (64.8) | 1490 (76.2) | <0.001 |
| Statins | 259 (18.4) | 1436 (20.1) | 0.140 | 540 (44.0) | 3980 (63.3) | <0.001 | 335 (37.7) | 2711 (51.9) | <0.001 | 168 (32.1) | 1679 (50.0) | <0.001 | 66 (24.7) | 953 (48.7) | <0.001 |
Data are represented as number of cases (n) and percentage proportion (%), if not stated otherwise. In variables where n (%) are reported, p-values were obtained by chi-square, whereas in variables where mean (SD) are reported, p-values were obtained by Student t-test. Patients who did not survive until the follow-up are excluded. Therapy was registered if a patient collected at least one prescription from the pharmacy in the 6-month period before the stroke, or 1st, 2nd, and 3rd year after stroke event. D, dementia; C, control; BPLM, blood pressure lowering medication; AF, atrial fibrillation. Missing values - medication at discharge: antiplatelets 33 (0.4), anticoagulants 7 (0.3), BPLM 36 (0.5), statins 42 (0.6).