Fig.6.

Effects of β-lactolin on memory function and tau accumulation in PS19 mice. Transgenic PS19 and wild-type male mice aged 3 months were fed a diet with or without 0.05% w/w β-lactolin or 5% w/w β-lactolin-rich whey enzymatic digestion (BL-W) for 6 months. Mice aged 9 months were subjected to the open field test to evaluate behavioral abnormality. A, B) The total distances in the open field (A) and in the center of the open field (B). C, D) The levels of phosphorylated tau (pTau, C) and total tau (D) in the cortex. E) The ratio of pTau to total tau. Data are presented as means±SEM (sample size: wild-type mice, 12; control transgenic mice, 11; transgenic mice fed with β-lactolin, 11; or transgenic mice fed with BL-W, 11). p-values shown in the graph were calculated by one-way ANOVA followed by the Tukey–Kramer test. *p < 0.05.