Table 1.

Mean blood pressure pre- and post-Aβ/saline infusion

Group	N	Weight* (g)	MBP: baseline (mmHg)	MBP:+zib (mmHg)	MBP: post-infusion final week (mmHg)
Aβ	20	343 (321–365)	102 (98–107)	–	105 (99–111)a
Saline	11	352 (325–379)	104 (101–107)	–	104 (99–109)
Aβ+zib	12	341 (299–383)	109 (103–115)	102 (95–109)b	104 (95–114)
Saline+zib	12	338 (327–349)	105 (102–108)	100 (97–102)c	101 (96–107)

Telemetry data (mean blood pressure; MBP) in Aβ- and saline-infused groups. Mean values (95% CI). *Weight prior to telemetry surgery at 12–14 weeks of age. Pre-infusion baseline MBP for all groups. MBP following Zibotentan (+zib) administration for Aβ+zib and saline+zib groups (measured pre-infusion). Post-infusion data for final week of Aβ or saline infusion (day 22–28). Baseline MBP did not differ significantly between groups (one-way ANOVA, p = 0.249). Final week MBP was significantly higher than baseline in the Aβ group (paired t-test, ^ap = 0.0404). MBP was significantly reduced in the Aβ+zib group (Tukey’s multiple comparisons test, ^bp = 0.0049) and the saline+zib group (Tukey’s, ^cp < 0.0001) following administration of Zibotentan.