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. 2020 Mar 15;12(3):267–275. doi: 10.4251/wjgo.v12.i3.267

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Expression of type I collagen and type IV collagen in normal tissue and colorectal cancer. A: Western blot showing the expression of type I collagen and type IV collagen; B: The expression of type I collagen in the extracellular matrix (ECM) of stages III and IV colorectal cancer was highest. In the ECM of stages I and II colorectal cancer, the expression was relatively low. The expression of type I collagen was positively associated with the stage of colorectal cancer (r = 0.706, P < 0.01); C: The expression of type IV collagen was negatively correlated with the stage of colorectal cancer (r = - 0.796, P < 0.01).