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. 2020 Mar 15;12(3):301–310. doi: 10.4251/wjgo.v12.i3.301

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Correlation analysis. A: Correlation between tumor necrosis alpha and progression free survival in all metastatic colorectal cancer (mCRC) patients (n = 17) (r_s = -0.52, P = 0.033); B: Correlation between transforming growth factor alpha and progression free survival in all mCRC patients (n = 17) (r_s = -0.52, P = 0.038); C: Correlation between tumor necrosis alpha and transforming growth factor alpha in all mCRC patients (n = 17) (r_s = 0.53, P = 0.028). P < 0.05 was considered the statistical significance. Each dot represents the value of one patients. Transforming growth factor alpha and tumor necrosis alpha are expressed as a concentration (pg/mL). Progression free survival is expressed in months. PFS: Progression free survival; TNF-α: Tumor necrosis alpha; TGF-β: Transforming growth factor alpha.