Study	Reason for exclusion
Bastin 2010	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators. Study design: threshold not used (Author's email on 14th August 2012)
Beckett 2010	Study design: threshold not used. The focus of the study was to compare annual changes in rCMRglc levels between MCI converters and MCI non‐converters at follow‐up (ADNI study).
Charil 2011	Study design: threshold not used. The focus of the study was to investigate annual changes in FDG‐PET scans in different study groups (ADNI study).
Chen 2010	Target condition: not conversion from MCI to dementia. Study design: threshold not used. The focus of the study was the measurement of the cerebral metabolic rate for glucose over a 12‐month period (ADNI study).
Chételat 2001	Study design: threshold not used. The focus of the study was to statistically compare initial PET data of people who developed ADD to those who did not at follow‐up.
Chételat 2005	Target condition: not conversion from MCI to dementia. Study design: threshold not used. The focus of the study was the measurement of the cerebral metabolic rate for glucose and comparison between that measurement and neuropsychological assessment in predicting global cognitive deterioration in people with MCI over an 18‐month period.
Desikan 2010	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared. Study design: threshold not used (ADNI study).
Drzezga 2003	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared. Study design: threshold not used. The focus of the study was to evaluate changes in the baseline and follow‐up ¹⁸F‐FDG‐PET scans.
Forsberg 2008	Study design: threshold not used. The focus of the study was to compare rCMRglc levels between MCI converters and MCI non‐converters at follow‐up.
Garibotto 2008	Study design: threshold not used. The focus of the study was to assess education and occupation as proxies for reserve in aMCI converters.
Gray 2012	Study design: threshold not used. The focus of the study was to investigate the value of combining cross‐sectional and longitudinal multi‐region FDG‐PET information for classification of Alzheimer's disease (ADNI study).
Hunt 2007	Study design: threshold not used. The focus of the study was to compare rCMRglc levels between MCI converters and MCI non‐converters at follow‐up.
Ishii 2009	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared. Study design: threshold not used. The focus of the study was to compare rCMRglc levels between MCI converters and MCI non‐converters at follow‐up.
Ishii 2011	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared.
Jagust 2007	Target condition: not conversion from MCI to dementia. Study design: threshold not used.
Kadir 2012	Study design: threshold not used. The focus of the study was to examine dynamic changes in FDG imaging at different stages of Alzheimer's disease.
Kawashima 2012	Study design: threshold not used. The focus of the study was to examine the association between baseline profiles and risk of early conversion to ADD (ADNI study).
Kim 2010	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators. Study design: threshold not used (Author's email on 4th October 2013)
Landau 2011	Study design: threshold not used. The focus of the study was to assess annual changes in biomarkers (ADNI study).
Landau 2012	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared
Lee 2011	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared.
Lo 2011	Target condition: not conversion from MCI to dementia. Study design: threshold not used. The focus of the study was to investigate rates of change in level of FDG uptake (ADNI study)..
Lo 2012	Target condition: not conversion from MCI to dementia. Study design: threshold not used. The focus of the study was to investigate the vascular contribution to longitudinal changes of rCMRglc in MCI and ADD participants (ADNI study).
Lorenzi 2010	Target condition: not conversion from MCI to dementia. Study design: threshold not used. The focus of the study was to assess the benefit of the enrichment of MCI participants with true Alzheimer's disease cases by means of ¹⁸F‐FDG‐PET scan and other biomarkers (ADNI study).
Lucidi 2012	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared.
Morbelli 2010	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared. Study design: threshold not used. The focus of the study was to concurrently investigate patterns of hypometabolism and athrophy in people with aMCI converted to ADD.
Morbelli 2012	Study design: threshold not used. The focus of the study was to explore resting‐state metabolic connectivity in people with aMCI who converted to ADD at follow‐up.
Pagani 2010	Study design: threshold not used. The focus of the study was to test the hypothesis that the combination of memory and brain metabolic assessment could identify subgroups of those MCI who would convert or would not convert to dementia at follow‐up.
Small 1995	Study design: threshold not used. The focus of the study was to investigate predictors of cognitive changes in middle‐aged and older adults with memory loss.
Torosyan 2011	Insufficient data to complete 2 x 2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared.
Walhovd 2010	Study design: threshold not used. The focus of the study was to combine FDG‐PET, MRI and CSF biomarkers in the 2‐year prognosis of MCI and Alzheimer's disease participants (ADNI study).
Zhang 2012	Insufficient data to complete 2X2 table. Additional data were requested from the trial investigators but no further information was available at the time this review was prepared. Study design: threshold not used. The focus of the study was to assess the predictive value of longitudinal and multimodal biomarkers in conversion from MCI to ADD (ADNI study).

ADD: Alzheimer's disease dementia
 ADNI: Alzhiemer's disease neurimaging initiative
 CSF: cerebro‐spinal fluid
 MCI: mild cognitive impairment
 MRI: magneitc resonance imaging