Table 2. Genetic Associations of Arachidonic Acid With Aortic Stenosis and Aortic Valve Calcium.
| Method | OR per 5–Percentage Point Increase of AA Among Total Fatty Acids (95% CI) | P Value |
|---|---|---|
| Aortic Stenosis | ||
| Mendelian randomization | 1.08 (1.04-1.13) | 4.1 × 10−4 |
| Excluding rs174547a | 1.03 (0.99-1.08) | .15 |
| Inverse variance-weighted | 1.08 (1.02-1.15) | 8.9 × 10−3 |
| Penalized weighted median | 1.11 (1.03-1.20) | 4.9 × 10−3 |
| Egger extension to mendelian randomization | 1.02 (0.92-1.13) | .72 |
| Intercept for the Egger extension | NA | .15 |
| Aortic Valve Calcium | ||
| Mendelian randomization | 1.23 (1.01-1.49) | .04 |
| Excluding rs174547a | 1.10 (0.82-1.49) | .52 |
| Inverse variance-weighted | 1.23 (1.01-1.49) | .04 |
| Penalized weighted median | 1.32 (1.04-1.68) | .02 |
| Egger extension to mendelian randomization | 1.08 (0.78-1.49) | .63 |
| Intercept for the Egger extension | NA | .32 |
Abbreviations: AA, arachidonic acid; NA, not applicable; OR, odds ratio.
a
Genetic risk score is not associated with eicosapentaenoic acid.