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. 2020 Mar 19;3:134. doi: 10.1038/s42003-020-0863-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Serum samples were obtained from 1698 lung cancer, 207 non-cancer patients in National Cancer Center biobank, and 1998 non-cancer participants in Yokohama Minoru Clinic. After excluding 132 samples from National Cancer Center biobank and 27 samples from Yokohama Minoru Clinic, the sample set was divided into two groups: the discovery set (N = 416) and validation set (N = 3328).