Table 1.
Patient characteristics in discovery and validation sets.
| Variables | Discovery set (N = 416) | Validation set (N = 3328) | ||||
|---|---|---|---|---|---|---|
| Lung cancer (N = 208) | Non-cancer (N = 208) | P Value | Lung cancer (N = 1358) | Non-cancer (N = 1970) | P Value | |
| Age, years ± SD | 60.2 ± 0.5 | 60.0 ± 0.5 | 0.7843 | 66.3 ± 0.3 | 50.3 ± 0.2 | <0.001 |
| Sex, n (%) | ||||||
| Men | 113 (54.3) | 103 (50.0) | 0.377 | 782 (57.6) | 1026 (52.1) | 0.002 |
| Women | 95 (45.7) | 105 (50.0) | 576 (42.4) | 944 (47.9) | ||
| Smoking status, n (%) | ||||||
| Former or current | 84 (40.4) | 83 (40.0) | 1.0 | 888 (65.4) | 399 (20.3) | <0.001 |
| Never | 124 (59.6) | 125 (60.1) | 470 (34.6) | 1571 (79.7) | ||
| Histology, n (%) | ||||||
| Adenocarcinoma | 179 (86.1) | – | – | 1038 (76.4) | – | – |
| Squamous carcinoma | 14 (6.7) | – | – | 207 (15.2) | – | – |
| Adenosquamous carcinoma | 1 (0.5) | – | – | 17 (1.3) | – | – |
| Small cell carcinoma | 1 (0.5) | – | – | 22 (1.6) | – | – |
| Other | 13 (6.3) | – | – | 74 (5.4) | – | – |
| Stage, n (%) | ||||||
| I (IA+ IB) | 155 (74.5) | – | – | 971 (71.5) | – | – |
| II (IIA+ IIB) | 26 (12.5) | – | – | 207 (15.2) | – | – |
| III (IIIA+ IIIB) | 22 (10.6) | – | – | 170 (12.5) | – | – |
| IV | 3 (1.4) | – | – | 8 (0.6) | – | – |
| 0 | 2 (1.0) | – | – | 2 (0.1) | – | – |