Table 4.
List of the most significant differently expressed biological pathways (P < 0.05) examined with KEGG database in mating (M), in comparison with the Control group.
| PATHWAY ID | PATHWAY NAME | ENRICHMENT SCORE | P-VALUE | GENES ALTERED% | GENE LIST | |
|---|---|---|---|---|---|---|
| EndoCvx | ||||||
| 1 | KEGG_103 | Steroid biosynthesis | 6.7 | 0.001 | 41.7 | CYP51, FAXDC2, MSMO1, NSDHL, SQLE |
| 2 | KEGG_8 | Glycosaminoglycan biosynthesis | 5.6 | 0.003 | 33.3 | CHST14, CHST3, CHSY1, CHSY3, DSE |
| 3 | KEGG_34 | Focal adhesion | 5.3 | 0.005 | 14.7 | ACTB, CAV1, CAV2, CDC42, COL1A2, COL3A1, COL6A3, COL6A3, ERBB2, HGF, IGF1R, ITGA2, ITGB6, MAPK1, ROCK2, THBS1, THBS3, VEGFB, ZYX |
| 4 | KEGG_49 | Adherens junction | 5 | 0.007 | 19.6 | ACTB, CDC42, CSNK2A2, CSNK2B, ERBB2, IGF1R, INSR, MAPK1, SNAI2 |
| DistEndom | ||||||
| 1 | KEGG_34 | Focal adhesion | 10.6 | 0.0002 | 25.2 | CCND2, COL11A1, COL1A2, COL3A1, COL4A1, COL4A6, COL5A2, COL6A3, COL6A3, COL6A3, ERBB2, FLT1, IGF1, IGF1R, ITGA1, ITGA2, ITGA5, ITGA8, ITGAV, ITGB6, LAMB1, MAPK1, MAPK8, PDGFC, PDGFD, SHC1, THBS1, THBS3, TLN2, VCL, VEGFA, VEGFB, ZYX |
| 2 | KEGG_213 | PI3K-Akt signaling pathway | 5.4 | 0.004 | 17.9 | CCND2, COL11A1, COL1A2, COL3A1, COL4A1, COL4A6, COL5A2, COL6A3, COL6A3, COL6A3, CREB3L1, CREB3L2, CREB5, CSF1R, CSF3, FGF17, FGF2, FGF20, FGFR1, FLT1, G6PC2, IGF1, IGF1R, IL7, ITGA1, ITGA2, ITGA5, ITGA8, ITGAV, ITGB6, LAMB1, MAPK1, MYB, PDGFC, PDGFD, PIK3AP1, PPP2R5D, STK11, THBS1, THBS3, VEGFA, VEGFB |
| 3 | KEGG_8 | Glycosaminoglycan biosynthesis | 5.2 | 0.005 | 40 | CHST12, CHST7, CHSY1, CHSY3, CSGALNACT2, DSE |
| 4 | KEGG_46 | Estrogen signaling pathway | 3.7 | 0.02 | 26.9 | CALM1, CREB3L1, CREB3L2, CREB5, FKBP4, HBEGF, HSPA2, MAPK1, MMP2, MMP9, PLCB4, PRKACA, SHC1 |
| 5 | KEGG_49 | Adherens junction | 3.2 | 0.03 | 21.7 | ERBB2, FGFR1, IGF1R, MAPK1, PTPN1, PVRL1, SNAI2, SORBS1, TCF7L2, VCL |
| ProxEndom | ||||||
| 1 | KEGG_34 | Focal adhesion | 8.8 | 0.0001 | 20.3 | BRAF, CCND2, COL1A2, COL3A1, COL4A1, COL5A2, COL6A3, COL6A3, COMP, CTNNB1, FIGF, FLT1, HGF, IGF1, IGF1R, ITGA1, ITGA2, ITGA8, KDR, LAMB1, MYLPF, PIK3R5, SHC1, TLN2, TNR, VEGFA |
| 2 | KEGG_213 | PI3K-Akt signaling pathway | 7.8 | 0.0004 | 16.5 | ANGPT2, CCND2, COL1A2, COL3A1, COL4A1, COL5A2, COL6A3, COMP, CREB3L1, CREB3L2, CREB3L4, CREB5, CSF1R, CSF3, EFNA2, FGF17, FGF21, FGF5, FGFR1, FIGF, FLT1, G6PC2, GH1, HGF, IGF1, IGF1R, IL7, ITGA1, ITGA2, ITGA8, KDR, LAMB1, PIK3AP1, PIK3R5, STK11, TNR, VEGFA |
| 3 | KEGG_98 | Rap1 signaling pathway | 6.3 | 0.001 | 17.5 |
ANGPT2, BRAF, CALM1, CSF1R, CTNNB1, EFNA2, FGF17, FGF21, FGF5, FGFR1, FIGF, FLT1, GNAS, GRIN2B, HGF, IGF1, IGF1R, KDR, PIK3R5, PLCB4, RAPGEF2, SIPA1L1 TLN2, VEGFA |
| 4 | KEGG_46 | Estrogen signaling pathway | 5.6 | 0.003 | 21.3 | CALM1, CREB3L1, CREB3L2, CREB3L4, CREB5, FKBP4, GNAS, HSPA2, KCNJ3, MMP9, PIK3R5, PLCB4, SHC1 |
| 5 | KEGG_105 | Cell adhesion molecules | 5.4 | 0.004 | 18.7 | CDH15, CLDN11, CLDN2, CLDN5, ITGA8, NRXN2, NTNG1, PVRL1, SDC1, SDC2, SDC4, SELL, SELP, SIGLEC1, SLA-8, VCAM1, VCAN |
| 6 | KEGG_165 | Mucin type O-Glycan biosynthesis | 4.5 | 0.01 | 28.6 | GALNTL5, GCNT1, GCNT3, GCNT4, ST3GAL1, ST6GALNAC1 |
| 7 | KEGG_8 | Glycosaminoglycan biosynthesis | 4.2 | 0.01 | 36.4 | B3GNT2, B4GALT1, CHST4, ST3GAL1 |
| UTJ | ||||||
| 1 | KEGG_103 | Steroid biosynthesis | 8.7 | 0.0007 | 21.4 | CYP51, FAXDC2, LIPA, MSMO1, NSDHL, SQLE |
| 2 | KEGG_110 | N-glycans biosynthesis | 4.8 | 0.008 | 21.6 | ALG13, B4GALT1, B4GALT3, DDOST, DPM3, MAN2A1, MGAT4B, STT3A |
| 3 | KEGG_8 | Glycosaminoglycan biosynthesis | 3.6 | 0.02 | 26.7 | B4GALT7, CHST12, CHSY3, DSE |
| Isth | ||||||
| 1 | KEGG_59 | Cell cycle | 6.7 | 0.001 | 20.3 | ANAPC13, ATM, CCNB2, CCND2, CDC20, CDC25C, EP300, ESPL1, FZR1, ORC4, PTTG1, RB1, STAG2, TP53, TTK |
| 2 | KEGG_34 | Focal adhesion | 3.5 | 0.03 | 13.8 | BRAF, CCND2, COL4A1, COL5A2, CTNNB1, ELK1, FIGF, HGF, IGF1R, LAMA4, MYLK2, PAK1, PTEN, SHC1, SOS2, SRC, VEGFB |
| 4 | KEGG_49 | Adherens junction | 3.2 | 0.03 | 17.4 | CTNNB1, EP300, IGF1R, SNAI2, SORBS1, SRC, SSX2IP, WASL |
| KEGG_98 | Rap1 signaling pathway | 3.2 | 0.04 | 13.1 | ADORA2A, BRAF, CTNNB1, FIGF, GNAI2, GNAO1, HGF, IGF1R, LPAR2, MAGI3, MAP2K6, MAPK14, P2RY1, PLCB4, RAPGEF6, RASGRP2, SRC, VEGFB | |
| Amp | ||||||
| 1 | KEGG_59 | Cell cycle | 12.4 | 0.0004 | 32.4 | ABL1, ANAPC13, BUB3, CCNA1, CCNB2, CCNB3, CCNE2, CCNH, CDC20, CDC23, CDC25B, CDC25C, CDC27, CDK1, CHEK1, E2F5, EP300, HDAC2, MCM4, MDM2, PTTG1, TTK, YWHAH, YWHAZ |
| 2 | KEGG_66 | FoxO signaling pathway | 6.4 | 0.001 | 23.7 | AKT2, ARAF, BCL2L11, BCL6, CCNB2, CCNB3, CHUK, EP300, FOXO3, IGF1R, INSR, KRAS, MAPK1, MAPK8, MDM2, PCK2, PIK3R5, PLK4, RAG1, RAG2, STAT3, USP7 |
| 3 | KEGG_195 | HIF-1 signaling pathway | 5.3 | 0.004 | 23.4 | AKT2, EGLN1, EGLN3, EIF4E, EP300, ERBB2, HK1, HKDC1, IFNGR1, IGF1R, INSR, MAPK1, NFKB1, PDHB, PIK3R5, RELA, STAT3, TCEB1 |
| 4 | KEGG_103 | Steroid biosynthesis | 4.5 | 0.01 | 41.7 | CYP24A1, HSD17B7, MSMO1, NSDHL, SQLE |
| 5 | KEGG_213 | PI3K-Akt signaling pathway | 3.8 | 0.02 | 17 | AKT2, BCL2L1, BCL2L11, CCNE2, CHUK, COL5A3, CRTC2, DDIT4, EFNA1, EIF4E, FGF19, FN1, FOXO3, GHR, GNB5, GNG11, HGF, IGF1R, INSR, ITGA11, ITGB4, KRAS, LPAR1, LPAR2, LPAR6, MAPK1, MDM2, NFKB1, PCK2, PIK3R5, PPP2R2A, RELA, TNC, TNR, TSC2, VEGFB, YWHAH, YWHAZ |
| 6 | KEGG_110 | N-glycans biosynthesis | 3.4 | 0.03 | 24.3 | ALG14, ALG5, B4GALT1, DAD1, DDOST, DOLPP1, MAN2A2, RPN1, STT3A |
| Inf | ||||||
| 1 | KEGG_59 | Cell cycle | 7.3 | 0.0006 | 28.4 | ANAPC13, BUB3, CCNB2, CCNB3, CCNE2, CDC20, CDC23, CDC25B, CDC25C, CDC27, CDK1, CDK6, CDKN2D, E2F3, EP300, FZR1, HDAC2, PTTG1, TGFB2, TTK, YWHAH |
| 2 | KEGG_49 | Adherens junction | 7.1 | 0.0008 | 32.6 | CDC42, CSNK2B, CTNNA3, EP300, ERBB2, IGF1R, IQGAP1, MAP3K7, MAPK1, MET, PTPN1, PVRL4, SNAI2, SORBS1, SSX2IP, TCF7L1 |
| 3 | KEGG_195 | HIF-1 signaling pathway | 6.7 | 0.001 | 27.3 | ANGPT1, CAMK2D, EGLN1, EGLN3, EIF4E, EP300, ERBB2, GAPDH, HK1, IFNGR1, IGF1, IGF1R, LTBR, MAPK1, MKNK2, NFKB1, NOS2, PDHB, RPS6, STAT3, TEK |
| 4 | KEGG_66 | FoxO signaling pathway | 5.8 | 0.002 | 24.7 | BCL2L11, BCL6, CAT, CCNB2, CCNB3, CDKN2D, CHUK, EP300, FOXO4, GABARAP, IGF1, IGF1R, KRAS, MAPK1, PLK4, PRKAB1, PRMT1, SIRT1, SOS2, STAT3, TGFB2, TNFSF10, USP7 |
| 5 | KEGG_110 | N-glycans biosynthesis | 4.7 | 0.008 | 29.7 | ALG14, ALG2, ALG5, DAD1, DDOST, DOLPP1, MAN1A1, MAN2A2, MGAT2, RPN1, STT3A |
| 6 | KEGG_103 | Steroid biosynthesis | 4.1 | 0.01 | 25.5 | CYP24A1, LIPA, MSMO1, NSDHL, SQLE |
*Upregulated genes are marked in bold; the unmarked were downregulated.
Endocervix (EndoCvx), Endometrium (DistEndom, ProxEndom), and endosalpinx from Utero-tubal Junction (UTJ), Isthmus (Isth), Ampulla (Amp) and Infundibulum (Inf).