Table 7.
List of the most significant differently expressed biological pathways (P < 0.05) examined with KEGG database in artificial deposition of sperm-free seminal plasma (SP) from entire ejaculate (SP-Ejac) group, in comparison with the Control group.
| PATHWAY ID | PATHWAY NAME | ENRICHMENT SCORE | P-VALUE | GENES ALTERED% | GENE LIST | |
|---|---|---|---|---|---|---|
| EndoCvx | ||||||
| 1 | KEGG_105 | Glycosaminoglycan biosynthesis | 3.5 | 0.03 | 20 | CHST3, CHST7, DSE |
| DistEndom | ||||||
| 1 | KEGG_66 | FoxO signaling pathway | 4.1 | 0.01 | 10.8 | ATG12, ATM, BCL6, CDKN2D, G6PC2, HOMER2, KRAS, MAPK10, PRKAB1, PRKAB2 |
| 2 | KEGG_59 | Cell cycle | 3.5 | 0.02 | 10.8 | ANAPC13, ANAPC5, ATM, CDKN2D, E2F3, HDAC2, SMC3, STAG2 |
| 3 | KEGG_105 | Glycosaminoglycan biosynthesis | 3.3 | 0.03 | 20 | CHST7, CHST12, CHST15 |
| ProxEndom | ||||||
| 1 | KEGG_213 | PI3K-Akt signaling pathway | 3.6 | 0.02 | 5.6 | COL5A3, CSF3, FGFR1, IFN-ALPHA-9, JAK1, MCL1, OSM, PKN3, PPP2R5D, PRLR, TN-X, TSC2 |
*Upregulated genes are marked in bold; the unmarked were downregulated.
Endocervix (EndoCvx), Endometrium (DistEndom, ProxEndom).