Figure 1.
B cells are not required for EAE induction or progression in PLP178–191-immunized B6 mice. WT or μMT mice were immunized s.c. with 100ug PLP178–191/CFA or MOG35–55/CFA on day 0 and given 250 ng pertussis toxin i.p. on days 0 and 2. (A,C) Clinical disease scores. (B,D) Cumulative disease index (CDI; measure of disease severity) depicts the summation of paralysis scores over time for each individual mouse in all groups. PLP178–191 groups: n = 30 WT; n = 30 μMT. MOG35–55 groups: n = 20 WT; n = 19 μMT. Data is representative of three independent experiments. ns = not significant; *p < 0.05; ****p < 0.0001.