Table 2. Differentially Expressed TFs Whose Binding Sites Are Enriched in the Different Developmental Stagesa.
| comparison | gene symbol | FC | description |
|---|---|---|---|
| hPSC vs DE | EOMES | 47.4 | eomesodermin |
| FOXA2 | 3.7 | forkhead box A2 | |
| GATA4 | 4.8 | GATA binding protein 4 | |
| KLF5 | 4.4 | Kruppel-like factor 5 (intestinal) | |
| NANOG | –3.8 | Nanog homeobox | |
| POU5F1 | –7.7 | POU class 5 homeobox 1 | |
| PRDM14 | –11.2 | PR domain containing 14 | |
| SOX2 | –17.6 | SRY (sex determining region Y)-box 2 | |
| DE vs hepatoblasts | AHR | 6.1 | aryl hydrocarbon receptor |
| E2F7 | –3.1 | E2F TF 7 | |
| EOMES | –47.0 | eomesodermin | |
| NANOG | –7.7 | Nanog homeobox | |
| hepatoblasts vs hPSC-HEP day 25 | CDX2 | 3.4 | caudal type homeobox 2 |
| KLF5 | 3.2 | Kruppel-like factor 5 (intestinal) | |
| hPSC-HEP day 25 vs AL | AR | 4.4 | AR |
| CDX2 | –5.2 | caudal type homeobox 2 | |
| KLF5 | –5.9 | Kruppel-like factor 5 (intestinal) |
a
FC > 0 upregulation in the second developmental stage in the comparison; FC < 0 upregulation in the first developmental stage in the comparison.