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. 2020 Mar 19;5:24. doi: 10.1038/s41541-020-0175-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MVA-specific (a) IgG, (b) IgA, and (c) IgM titers were measured by direct enzyme-linked immunosorbent assay (ELISA) in macaque serum over time. Comparisons of MVA-specific (d) IgG and (e) IgA titers were performed at the indicated timepoints between studies by aligning both vaccine schedules with respect to the date of the second immunization (2 weeks or 2 months after the first immunization). f MVA-nAb titers were quantified in serum using a single-cycle infection assay at the indicated timepoints. g The binding of serum MVA-specific IgG to FcγRIIIa was measured by ELISA using serum diluted as 1:500 and expressed as optical density (OD). Comparisons of (h) MVA-nAb titers and i binding of MVA-specific IgG to FcγRIIIa were performed at the indicated timepoints between studies. Immunizations are indicated by arrows. Colors indicate the vaccine regimen: first and second immunization 2 weeks (red), or 2 months (black) later. Individual titers or ODs are shown. Comparisons were performed using permutation tests (*p < 0.05, **p < 0.01).