Table 2.
Meta-analysis of IL17A variants, Latin American cohorts for T. cruzi infection susceptibility (seropositive vs. seronegative individuals).
| Colombian cohort | Argentinian cohort | Brazilian cohort | Meta-analysis | |||||
|---|---|---|---|---|---|---|---|---|
| SNP | OR (L95-U95) | P | OR (L95-U95) | P | OR (L95-U95) | P | OR (L95-U95) | P |
| rs4711998*A | 0.94 (0.78–1.14) | 0.528 | 1.38 (0.90–2.12) | 0.143 | — | — | 0.99 (0.84–1.17) | 0.946 |
| rs8193036*C | 0.83 (0.70–0.99) | 0.043 | 1.34 (0.89–20.2) | 0.164 | — | — | 0.89 (0.76–1.05) | 0.169 |
| rs2275913*A | 1.16 (0.95–1.4) | 0.136 | 1.07 (0.67–1.69) | 0.793 | 1.46 (1.05–2.05) | 0.032 | 1.21 (1.06-1.41) | 0.016 |
Total number of individuals: rs4711998 and rs8193036: seropositive, n = 1209 and seronegative, n = 718; rs2275913: seropositive, n = 1469 and seronegative, n = 868. OR: odds ratios, L95-U95: confidence intervals of 95% L: lower limit; U: upper limit. Significant P value is shown in bold. Significant association based on the Bonferroni correction P < 0.017.