Table 4.
Meta-analysis of IL17A variants, Latin American cohorts for chronic cardiomyopathy susceptibility (CCC vs. seronegative individuals).
| Colombian cohort | Argentinian cohort | Brazilian cohort | Meta-analysis | |||||
|---|---|---|---|---|---|---|---|---|
| SNP | OR (L95-U95) | P | OR (L95-U95) | P | OR (L95-U95) | P | OR (L95-U95) | P |
| rs4711998*A | 0.93 (0.75–1.16) | 0.541 | 1.47 (0.92–2.37) | 0.109 | — | — | 1.02 (0.82–1.23) | 0.927 |
| rs8193036*C | 0.84 (0.67–1.05) | 0.133 | 1.21 (0.78–1.88) | 0.389 | — | — | 0.91 (0.74–1.10) | 0.323 |
| rs2275913*A | 1.14 (0.90–1.44) | 0.298 | 0.99 (0.60–1.61) | 0.955 | 1.52 (1.08–2.15) | 0.021 | 1.20 (1.01–1.45) | 0.040 |
Total number of individuals: rs4711998 and rs8193036: CCC, n = 758 and seronegative, n = 718; rs2275913: CCC, n = 970 and seronegative, n = 868. OR: odds ratios, L95-U95: confidence intervals of 95% L: lower limit; U: upper limit.