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. 2020 Mar 19;10:5062. doi: 10.1038/s41598-020-61992-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Univariable KM survival curves between patients grouped by highest and lowest immunogenicity (Ϊ) and immune activity marker expression (CYT) scores for the (A,B) lung (NSCLC) and (C,D) melanoma (SKCM) TCGA cohorts. Quantiles of I and CYT patient scores used to group cohorts with the lowest and highest groups represented by the curves; (E,F) Time dependent Brier scores (prediction error curves) comparing multivariable cox proportional hazard survival models for the NSCLC cohort (E), and SKCM cohort (F). Reference is intercept, all other models include tumor stage covariates. TMB includes patient tumor mutation burden, TMB_I includes immunogenicity and TMB, CYT_TMB includes CYT and TMB. Vertical lines demarcate approximately 80% of the patients, for which integrated Brier scores were calculated.