Table 3.
Evaluation of the correlation between COL6A5 variants and lung cancer susceptibility among Chinese Han population.
| SNP | Allele/Genotype | Control N (%) | Case N (%) | OR (95% CI) | p value |
|---|---|---|---|---|---|
| rs77123808 | A | 638 (64.44%) | 675 (66.18%) | 1.00 | 0.415 |
| C | 352 (35.56%) | 345 (33.82%) | 0.93 (0.77–1.11) | ||
| AA | 205 (41.41%) | 221 (43.33%) | 1.00 | ||
| AC | 228 (46.06%) | 233 (45.69%) | 0.96 (0.73–1.24) | 0.735 | |
| CC | 62 (12.53%) | 56 (10.98%) | 0.85 (0.56–1.27) | 0.423 | |
| rs10212241 | C | 555 (56.17%) | 573 (56.18%) | 1.00 | 0.999 |
| T | 433 (43.83%) | 447 (43.82%) | 1.00 (0.84–1.19) | ||
| CC | 156 (31.58%) | 163 (31.96%) | 1.00 | ||
| CT | 243 (49.19%) | 247 (48.43%) | 0.97 (0.73–1.29) | 0.858 | |
| TT | 95 (19.23%) | 100 (19.61%) | 1.01 (0.71–1.45) | 0.950 | |
| rs13062453 | G | 664 (67.21%) | 646 (63.46%) | 1.00 | 0.078 |
| A | 324 (32.79%) | 372 (36.54%) | 1.18 (0.98–1.42) | ||
| GG | 230 (46.56%) | 203 (39.88%) | 1.00 | ||
| GA | 204 (41.30%) | 240 (47.15%) | 1.33 (1.02–1.74) | 0.036* | |
| AA | 60 (12.15%) | 66 (12.97%) | 1.21 (0.81–1.81) | 0.346 | |
| rs1497305 | G | 710 (72.45%) | 722 (71.06%) | 1.00 | 0.492 |
| A | 270 (27.55%) | 294 (28.94%) | 1.07 (0.88–1.30) | ||
| GG | 265 (54.08%) | 247 (48.62%) | 1.00 | ||
| GA | 180 (36.73%) | 228 (44.88%) | 1.37 (1.05–1.78) | 0.019* | |
| AA | 45 (9.18%) | 33 (6.50%) | 0.76 (0.47–1.24) | 0.269 |
SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% confidence interval.
The OR and 95% CI were calculated by logistic regression analysis.
p value was obtained by Wald test with adjustment for age and gender.
*Statistically significant results are in bold (p < 0.05).