Table 5.
Significant COL6A5 variants in stratified analysis for pathological type.
| SNP | Allele/Genotype | Control (N = 495) | Lung Adenocarcinoma | Squamous Cell Carcinoma | ||||
|---|---|---|---|---|---|---|---|---|
| Case (N = 188) | OR (95% CI) | pa-value | Case (N = 120) | OR (95% CI) | pa-value | |||
| rs13062453 | G | 664 (67.21%) | 233 (61.97%) | 1.00 | 0.068 | 157 (65.97%) | 1.00 | 0.715 |
| A | 324 (32.79%) | 143 (38.03%) | 1.26 (0.98–1.61) | 81 (34.03%) | 1.06 (0.78–1.43) | |||
| GG | 230 (46.56%) | 70 (37.23%) | 1.00 | 52 (43.70%) | 1.00 | |||
| GA | 204 (41.30%) | 93 (49.47%) | 1.46 (1.01–2.11) | 0.045* | 53 (44.54%) | 1.18 (0.76–1.83) | 0.456 | |
| AA | 60 (12.15%) | 25 (13.30%) | 1.27 (0.74–2.20) | 0.391 | 14 (11.76%) | 1.07 (0.55–2.09) | 0.847 | |
| rs1497305 | G | 710 (72.45%) | 261 (69.41%) | 1.00 | 0.267 | 168 (70.59%) | 1.00 | 0.566 |
| A | 270 (27.55%) | 115 (30.59%) | 1.16 (0.89–1.50) | 70 (29.41%) | 1.10 (0.80–1.50) | |||
| GG | 265 (54.08%) | 93 (46.73%) | 1.00 | 59 (49.58%) | 1.00 | |||
| GA | 180 (36.73%) | 97 (48.74%) | 1.76 (1.23–2.51) | 0.002* | 50 (42.02%) | 1.24 (0.81–1.91) | 0.323 | |
| AA | 45 (9.18%) | 9 (4.52%) | 0.59 (0.27–1.27) | 0.180 | 10 (8.40%) | 1.08 (0.50–2.31) | 0.848 | |
SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% confidence interval.
The OR and 95% CI were calculated by logistic regression analysis.
p value was obtained by Wald test with adjustment for age and gender.
*Statistically significant results are in bold (p < 0.05).