Table 2.
Crude/unadjusted and adjusted Cox regression analysis of the association between dsDNA and all-cause mortality. The adjusted multivariable model included age, sex, smoking, leukocyte count, platelet count, NT-proBNP, fasting glucose, CRP and D-dimer as potential covariates.
| n | Univariable analysis | Multivariable analysis (n = 907) | |||||
|---|---|---|---|---|---|---|---|
| Unadjusted HR | 95% CI | p* | Adjusted HR | 95% CI | p* | ||
| dsDNA Q3 vs. Q1+2 | 956 | 2.03 | 1.12 to 3.66 | 0.019 | 1.89 | 1.03 to 3.49 | 0.041 |
| dsDNA Q4 vs. Q1+2 | 956 | 3.36 | 1.95 to 5.78 | <0.001 | 2.28 | 1.19 to 4.36 | 0.013 |
| Age | 956 | 1.09 | 1.07 to 1.12 | <0.001 | 1.10 | 1.07 to 1.13 | <0.001 |
| Male vs. female sex | 956 | 0.40 | 0.25 to 0.64 | <0.001 | 0.77 | 0.45 to 1.32 | 0.344 |
| Current smoking (+/−) | 956 | 0.87 | 0.55 to 1.36 | 0.535 | 1.89 | 1.11 to 3.24 | 0.020 |
| Leukocyte count | 953 | 1.03 | 1.00 to 1.06 | 0.025 | 0.94 | 0.87 to 1.02 | 0.136 |
| Platelet count | 952 | 1.01 | 1.00 to 1.01 | <0.001 | 1.01 | 1.00 to 1.01 | 0.001 |
| NT-proBNP | 926 | 1.00 | 1.00 to 1.00 | <0.001 | 1.00 | 1.00 to 1.00 | 0.049 |
| Fasting glucose | 947 | 1.17 | 1.05 to 1.29 | 0.003 | 1.25 | 1.11 to 1.40 | <0.001 |
| CRP | 955 | 1.01 | 1.00 to 1.01 | 0.022 | 1.00 | 1.00 to 1.01 | 0.830 |
| D-dimer | 950 | 1.00 | 1.00 to 1.00 | <0.001 | 1.00 | 1.00 to 1.00 | 0.051 |
| Previous CVD (+/−) | 955 | 2.25 | 1.42 to 3.56 | 0.001 | |||
| Peak TnT | 956 | 1.03 | 0.99 to 1.07 | 0.150 | |||
| Prehospital thrombolysis (+/−) | 956 | 0.21 | 0.05 to 0.86 | 0.030 | |||
| Time (symptom onset to blood sampling) | 951 | 1.00 | 0.99 to 1.01 | 0.722 | |||
Hazard ratios per one unit increase in the explanatory variables, except where otherwise stated, e.g. presence/absence of categorical variables (+/−). *p-value corresponding to Wald test.