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. 2020 Mar 19;10:5046. doi: 10.1038/s41598-020-61251-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bone measurements taken at 4-months of age indicate skeletal differences between NF1^+/ex42del (N = 8) and wildtype minipigs (N = 4). (a) long bone measurement boxplots with repeated measures’ CCC values, (b) additional long bone and cranial cavity measurement boxplots with repeated measures’ CCC values, (c) tibial bowing assessment plotted with dashed lines indicating range and median values for wildtype siblings. Definition of abbreviations: CCC – concordance correlation coefficient; L – length; W – width; NF1 – neurofibromatosis 1; mm – millimeters; *– p < 0.05; **– p < 0.01.