. Author manuscript; available in PMC: 2020 Mar 19.

Published in final edited form as: J Gastrointest Cancer. 2015 Dec;46(4):390–398. doi: 10.1007/s12029-015-9764-6

Table 4.

The associations between PKM2 expression and selected prognostic factors with overall survival form the multivariable Cox model

	Overall survival^a
Variables	HR	95 % CI	p value
Age at surgery (73 vs 57.2)^b	1.18	0.83–1.68	0.048
PKM2 expression (positive vs negative)	0.57	0.36–0.91	0.017
Surgical margin status (positive vs negative)	1.54	0.95–2.49	0.079
Perineural invasion (positive vs negative	0.81	0.46–1.43	0.471
Peripancreatic extension (positive vs negative)	2.36	1.21–4.60	0.012

The multivariable Cox model stratified on adjuvant chemotherapy (yes or no)

Age at surgery was included in the model nonlinearly by using a restricted cubic spline with three knots. Reported here is the HR for upper quartile vs lower quartile, the p value reported is for the whole curve