Comparison 1. Hydrocortisone (10 mg/m²/day to 15 mg/m²/day) versus prednisolone (2.4 mg/m²/day to 3.5 mg/m²/day).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 17 OHP	1	44	Mean Difference (IV, Fixed, 95% CI)	1189.10 [‐51.08, 2429.28]
1.1 At 1 year (pre‐pubertals)	1	21	Mean Difference (IV, Fixed, 95% CI)	1436.0 [‐127.38, 2999.38]
1.2 At 1 year (pubertals)	1	23	Mean Difference (IV, Fixed, 95% CI)	770.0 [‐1266.86, 2806.86]
2 Androstenedione	1	45	Mean Difference (IV, Fixed, 95% CI)	57.75 [11.19, 104.31]
2.1 At 1 year (pre‐pubertals)	1	21	Mean Difference (IV, Fixed, 95% CI)	63.0 [‐4.57, 130.57]
2.2 At 1 year (pubertals)	1	24	Mean Difference (IV, Fixed, 95% CI)	53.0 [‐11.25, 117.25]
3 Testosterone	1	44	Mean Difference (IV, Fixed, 95% CI)	38.55 [‐6.48, 83.58]
3.1 At 1 year (pre‐pubertals)	1	21	Mean Difference (IV, Fixed, 95% CI)	35.0 [‐29.13, 99.13]
3.2 At 1 year (pubertals)	1	23	Mean Difference (IV, Fixed, 95% CI)	42.0 [‐21.24, 105.24]
4 Height SDS BA	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
4.1 At 1 year	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Height SDS CA	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
5.1 at 1 year	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Ratio BA/CA	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
6.1 at 1 year	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Growth velocity SDS	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
7.1 At 1 year	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Height cm	1		Std. Mean Difference (IV, Fixed, 95% CI)	Totals not selected
8.1 At 1 year	1		Std. Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]