Database	Strategy	Date last searched	Records identified
CENTRAL	#1 MeSH descriptor: [Adrenal Hyperplasia, Congenital] this term only [MeSH descriptor] #2 Adrenal Hyperplasia [all text] #3 hydroxylase deficiency [all text] #4 #1 AND #2 AND #3 #5 Mesh descriptor: [Glucocorticoids] this term only #6 (hydrocortisone or chronocort or plenadren or beclomethasone or betamethasone or budesonide or cortisone or dexamethasone or methylprednisolone or prednisolone or prednisone or triamcinolone) #7#5 or #6 #8 #4 and #7 [limit to trials only]	17 December 2019	71
MEDLINE Ovid	1 randomized controlled trial.pt. 2 controlled clinical trial.pt. 3 randomized.ab. 4 placebo.ab. 5 drug therapy.fs. 6 randomly.ab. 7 trial.ab. 8 groups.ab. 9 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 10 exp animals/ not humans.sh. 11 9 not 10 12 Adrenal Hyperplasia, Congenital/ 13 Adrenal Hyperplasia.af. 14 21‐hydroxylase deficiency.af. 15 12 or 13 or 14 16 Glucocorticoids/ 17 (hydrocortisone or chronocort or plenadren or beclomethasone or betamethasone or budesonide or cortisone or dexamethasone or methylprednisolone or prednisolone or prednisone or triamcinolone).af. 18 16 or 17 19 11 and 15 and 18 Lines 1‐11 are the Cochrane Highly Sensitive Search Strategy for identifying randomised trials in MEDLINE: sensitivity‐maximizing version (2008 revision); Ovid format (Lefebvre 2011).	17 December 2019	1042
Embase HDAS (1974 to present) ‐ including RCT subject headings in filter	1 ''CONGENITAL ADRENAL HYPERPLASIA''/ 2 (Adrenal Hyperplasia).af 3 ''STEROID 21 MONOOXYGENASE DEFICIENCY''/ 4 (21‐hydroxylase deficiency).af 5 (1 OR 2 OR 3 OR 4) 6 Exp GLUCOCORTICOID/ 7 (hydrocortisone OR chronocort OR plenadren OR beclomethasone OR betamethasone OR budesonide OR cortisone OR dexamethasone OR methylprednisolone OR prednisolone OR prednisone OR triamcinolone).af 8 6 OR 7 9 (''CROSSOVER PROCEDURE''/ OR ''DOUBLE BLIND PROCEDURE'' OR ''RANDOMIZED CONTROLLED TRIAL'' OR ''SINGLE BLIND PROCEDURE'').af 10 (random* OR factorial* OR crossover* OR (cross* ADJ over*) OR placebo*).af 11 ((doubl* ADJ3 blind*) OR (singl* ADJ3 blind*) OR assign* OR allocat* OR volunteer*).af 12 (9 OR 10 OR 11) 13 (5 OR 8 OR 12) Embase search strategy (Lefebvre 2011)	17 December 2019	261
ISRCTN (www.isrctn.com)	[Basic Search] ''Adrenal hyperplasia'' OR ''21‐hydroxylase deficiency''	17 December 2019	25
Clinicaltrials.gov (www.clinicaltrials.gov)	[Advanced Search] Condition: '' congenital adrenal hyperplasia'' STUDY TYPE: Interventional Studies	17 December 2019	76
WHO ICTRP (apps.who.int/trialsearch)	[Basic search] Adrenal hyperplasia OR 21‐hydroxylase deficiency	17 December 2019	83 (76 trials)
Health Canada’s Clinical Trial Database (health‐products.canada.ca/ctdb‐bdec/index‐eng.jsp)	SEARCH 1 Medical condition: adrenal hyperplasia SEARCH 2: Medical condition: 21 hydroxylase deficiency	17 December 2019	0
NICE Evidence (www.evidence.nhs.uk)	''adrenal hyperplasia'' OR ''21‐hydroxylase deficiency''	17 December 2019	134