COCA.

Trial name or title	COrticosteroid in Congenital Adrenal Hyperplasia (COCA)
Methods	Open‐label RCT. Cross‐over design. Location: Caen, France. Duration: 8 weeks.
Participants	40 participants. Age: 18 years and above. Gender: females only eligible. Diagnosis: classical CAH due to 21OH deficiency.
Interventions	Group 1: HC equivalent to physiological doses for each participant. Group 2: DXA equivalent to physiological doses for each participant. Group 3: PD equivalent to physiological doses for each participant.
Outcomes	Primary outcomes: salivary 17 OHP, plasma ACTH, testosterone, androstenedione. Secondary outcomes: CTX, P1NP, bone alkaline phosphatase, blood glucose and insulin, lipid profile, QoL.
Starting date	August 2012.
Contact information	Yves Reznik, MD, PhD.
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