PULSES.

Trial name or title	Pulsed glucocorticoid replacement therapy for patients with adrenocortical insufficiency secondary to Addison’s disease and congenital adrenal hyperplasia ‐ the pulses study
Methods	Open‐label RCT. Parallel design. Location: Bristol, UK. Duration: 6 weeks.
Participants	122 participants. Age: 18 ‐ 64 years. Gender: females and males both eligible. Diagnosis: classical CAH due to 21‐hydroxylase deficiency.
Interventions	Arm 1: HC + placebo infusion. Arm 2: oral placebo + HC infusion.
Outcomes	Primary: ACTH in all participants and 17 OHP in people with CAH using subcutaneous pulsatile HC replacement. Secondary: cognitive, EMA, metabolic profile.
Starting date	November 2014.
Contact information	Dr Georgina Russell.
Notes