Table 5. No. of Litters, No. of Live Fetuses, and Maternal Lethality Rate in Dams Exposed to Valproic Acid (500 mg/kg) Per Se and in Combination with Vit. C (2000 + 8000 mg/kg), Selenium (100 + 200 μg/kg), and Grape Seed (300 + 600 mg/kg)a.
| treatment groups | no. of litters | no. of live fetuses | maternal death rate |
|---|---|---|---|
| N.C | 8.1 ± 0.3 | 8.8 ± 0.44 | 0.0 ± 0.00 |
| D.C V.P (500 mg/kg) | 2.7 ± 1.11 | 3 ± 0.33 | 0.6 ± 0.16 |
| V.P + Vit. C (500 mg + 2000 mg/kg) | 3.3 ± 1.01* | 5.8 ± 1.2 | 0.2 ± 0.13a |
| V.P + Vit. C (500 mg + 8000 mg/kg) | 5.2 ± 0.95 | 8.6 ± 0.59a | 0.2 ± 0.13a |
| V + Se (500 mg + 100 μg/kg) | 4.4 ± 1.24 | 6.8 ± 1.02a | 0.2 ± 0.13a |
| V.P + Se (500 mg + 200 μg/kg) | 2.6 ± 1.08* | 6.3 ± 1.19 | 0.0 ± 0.00a |
| V.P + G.S (500 mg + 300 mg/kg) | 4.3 ± 1.20 | 3.7 ± 1.09 | 0.0 ± 0.00a |
| V.P + G.S (500 mg + 600 mg/kg) | 5.1 ± 1.02 | 6.8 ± 1.22 | 0.0 ± 0.00a |
a
Data are represented as mean ± SEM, n = 10; aP < 0.05 was given in comparison to the disease control group with the no. of live fetuses and maternal death rate. Mean ± SEM, *P < 0.05 was given in no. of litters compared with N.C.