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. 2020 Mar 2;5(10):4953–4961. doi: 10.1021/acsomega.9b03792

Table 6. Incidence of Gross Morphological Abnormalities in Rat Fetuses after Treatment with Valproic Acid and in Combination with Antioxidantsa.

treatment groups crown rump length (cm) fetal growth retardation (cm)
N.C 3.2 ± 0.4 0.0 ± 0.00
D.C V.P (500 mg/kg) 0.73 ± 0.15 1.11 ± 0.35
V.P + Vit. C (500 mg + 2000 mg/kg) 1.25 ± 0.27 0.4 ± 0.22
V.P + Vit. C (500 mg + 8000 mg/kg) 1.71 ± 0.32 0.2 ± 0.13*
V.P + Se (500 mg + 100 μg/kg) 1.55 ± 0.25 0.2 ± 0.13*
V.P + Se (500 mg + 200 μg/kg) 0.49 ± 0.09 0.5 ± 0.22
V.P + G.S (500 mg + 300 mg/kg) 1.58 ± 0.28 0.4 ± 0.26
V.P + G.S (500 mg + 600 mg/kg) 1.96 ± 0.37* 0.0 ± 0.00**
a

Data are represented as mean ± SEM, n = 10; *P < 0.05, **P < 0.01were given in comparison to the disease control group.