Table 6. Incidence of Gross Morphological Abnormalities in Rat Fetuses after Treatment with Valproic Acid and in Combination with Antioxidantsa.
treatment groups | crown rump length (cm) | fetal growth retardation (cm) |
---|---|---|
N.C | 3.2 ± 0.4 | 0.0 ± 0.00 |
D.C V.P (500 mg/kg) | 0.73 ± 0.15 | 1.11 ± 0.35 |
V.P + Vit. C (500 mg + 2000 mg/kg) | 1.25 ± 0.27 | 0.4 ± 0.22 |
V.P + Vit. C (500 mg + 8000 mg/kg) | 1.71 ± 0.32 | 0.2 ± 0.13* |
V.P + Se (500 mg + 100 μg/kg) | 1.55 ± 0.25 | 0.2 ± 0.13* |
V.P + Se (500 mg + 200 μg/kg) | 0.49 ± 0.09 | 0.5 ± 0.22 |
V.P + G.S (500 mg + 300 mg/kg) | 1.58 ± 0.28 | 0.4 ± 0.26 |
V.P + G.S (500 mg + 600 mg/kg) | 1.96 ± 0.37* | 0.0 ± 0.00** |
Data are represented as mean ± SEM, n = 10; *P < 0.05, **P < 0.01were given in comparison to the disease control group.