Figure 10.

Proposed pathway that underlies cell migration driven by localized mechanically activated integrin. High concentrations of accumulated proteins at the plasma membrane induce a decrease in membrane tension and inward membrane curvature, which exerts a mechanical force on integrin and activates it. Higher integrin activity leads to SFK and ERK activation downstream. SFKs and ERK activate RhoA GEFs, LARG and GEF-H1. The resulting RhoA activation leads to ROCK activation, increased actomyosin contractility, rearward plasma membrane flow, further lowering of tension at the back, and integrin activation.