Table 2.

Toxicity Results.

Toxicity	Cohort 1 (n = 3), Grade ≤2/≥3	Cohort 2 (n = 4), Grade ≤2/≥3	Cohort 3 (n = 4), Grade ≤2/≥3
Noncardiac chest pain	1/0	0/0	0/0
Hot flashes	3/0	0/0	0/0
Headache	1/0	0/0	0/0
Nausea	1/0	0/0	1/0
Back pain	1/0	0/0	1/0
Fatigue	1/0	1/0	0/0
Dyspepsia	1/0	1/0	0/0
Anorexia	1/0	1/0	0/0
Tumor pain	1/0	0/0	0/0
Laryngeal fistula	1/0	0/0	0/0
Dyspnea	0/0	1/0	0/0
Anxiety	0/0	1/0	0/0
Weight loss	0/0	1/0	0/0
Abdominal pain	0/0	2/0	0/0
Diarrhea	0/0	1/0	2/0
Aspartate aminotransferase increased	0/0	1/0	1/0
Generalized muscle weakness	0/0	0/0	1/0
Neoplasms benign	0/0	0/0	1/0
Constipation	0/0	0/0	1/0
Fever	0/0	0/0	1/0
Dizziness	0/0	0/0	1/0
Urinary urgency	0/0	0/0	1/0