Table 3.

Selected Ongoing Studies in the Neonatal Neurosciences at Johns Hopkins.

HIE	Basic science studies on white matter injury following HIE Serum biomarkers of asphyxia Feeding and growth following neonatal HI and therapeutic hypothermia Study of Perinatal brain injury Recovery and OUTcome (SPROUT): Early building blocks of higher order cognition Preclinical evaluation of executive function in HIE
Prematurity	Serum biomarkers of white matter injury in pre-term infants Preterm erythropoietin neuroprotection trial Translational investigations on pain neural circuit formation, pain perception, and pain processing in preterm infants Basic science studies on inflammatory signal transduction in maternal–placental–fetal axis and encephalopathy of prematurity Mechanisms of lifelong neuroinflammation from chorioamnionitis Preclinical integration of cognitive and motor deficits in cerebral palsy
Hydrocephalus	Preclinical investigations on novel, nonsurgical therapies for posthemorrhagic hydrocephalus of prematurity and hydrocephalus in preterm and term infants Neuroimaging and neurodevelopmental outcome in infants with posthemorrhagic hydrocephalus of prematurity
Neurodevelopment	Longitudinal study of infants with neonatal encephalopathy School age needs after neonatal HI Survey of academic performance in children with a history of neonatal encephalopathy Translational and basic science studies of neonatal opioid exposure and withdrawal in preterm and term infants, including fluid, neuroimaging, and biobehavioral biomarkers of impaired neurodevelopment
Neuroimaging	MRI/DTI as a predictor of outcome following neonatal HI Prevalence of intracranial hemorrhage, including subpial hemorrhages Imaging features among neonatal patients exposed to drugs of abuse during pregnancy
Autoregulation	Autoregulation during hypothermia and rewarming
Seizures	Mechanisms of seizures during prematurity Susceptibility of males versus females to seizures following neonatal HI Optimal recording methods for detection of neonatal seizures

Abbreviations: HIE, hypoxic–ischemic encephalopathy; NICN, Neurosciences Intensive Care Nursery; HI, hypoxic–ischemic; MRI, magnetic resonance imaging; DTI, diffusion tensor imaging.