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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Biomaterials. 2019 Jun 21;217:119292. doi: 10.1016/j.biomaterials.2019.119292

Figure 9. Example particle utilizing cerium as an ROS scavenger.

Figure 9

(a) Schematic of how the cerium containing particles are oxidized to scavenge excessive surrounding ROS to prevent cellular damage. The particles containing zirconia have a higher Ce (III) to Ce(IV) ratio than typical ceria nanoparticles and therefore are more readily oxidized and scavenge ROS more effectively. (b) The particles were used to treat an inflammation model in the cecum and stomach. CD68 positive cells, which are innate immune cells, were stained in green to assess the magnitude of the inflammatory response in a cecal ligation and puncture-induced bacteremia mouse model. In addition, the overall survival of the mice after infection and treatment was assessed. Reprinted (adapted) with permission from [172]. Copyright 2017 John Wiley and Sons.