Table 1.
Hematological analysis data of STX-0119 treated mice
| Parameter | Control (n=8) | STX-0119 (80mg/kg, n=7) | STX-0119 (160mg/kg, n=7) | ||
|---|---|---|---|---|---|
| Mean±SD | Mean±SD | p-value(T-test) | Mean±SD | p-value(T-test) | |
| WBC(X10³ cell/μl) | 5.59±2.25 | 4.58±2.5 | 0.444 | 2.49±.87 | 0.005 |
| RBC(X106 cell/μl) | 8.29±.82 | 8.37±.60 | 0.839 | 8.32±.48 | 0.929 |
| HGB(g/dl) | 13.51±.69 | 13.17±.91 | 0.444 | 13.01±.68 | 0.199 |
|
HCT(%) (37-55) |
45.00±3.40 | 44.83±3.48 | 0.927 | 42.94±1.53 | 0.170 |
| MCV(fL) | 54.47±2.57 | 53.6±1.89 | 0.484 | 51.7±1.34 | 0.026 |
| MCH(pg) | 16.41±1.17 | 15.77±.63 | 0.224 | 15.66±.57 | 0.149 |
| MCHC(g/dl) | 30.13±1.59 | 29.41±.48 | 0.277 | 30.33±1.05 | 0.786 |
| RDW(%) | 14.11±2.73 | 13.04±1.06 | 0.352 | 13.27±.95 | 0.456 |
| PLT(X10³ cell/μl) | 1014.86±239.79 | 1273.86±191.19 | 0.045 | 1116.29±201.41 | 0.408 |
| MPV(fL) | 5.79±0.34 | 5.94±0.28 | 0.368 | 6.19±0.72 | 0.207 |
| NEUT(%) | 26.27±6.18 | 30.96±6.87 | 0.205 | 29.26±5.23 | 0.349 |
| LYM(%) | 65.26±5.65 | 62.17±6.09 | 0.345 | 63.27±4.42 | 0.478 |
| MONO(%) | 0.8±0.24 | 1.03±0.43 | 0.243 | 0.8±0.38 | 1.000 |
| EOS(%) | 1.46±0.42 | 1.87±1.09 | 0.366 | 2.37±0.63 | 0.008 |
| LUC(%) | 6.11±5.58 | 3.86±2.68 | 0.354 | 4.16±5.77 | 0.531 |
| BASO(%) | 0.07±0.08 | 0.11±0.09 | 0.354 | 0.11±0.11 | 0.403 |
WBC White Blood Cells, RBC Red Blood Cells, HGB Hemoglobin, HCT Hematocrit, MCV Mean Corpuscular Volume, MCH Mean Corpuscular Hemoglobin, MCHC Mean Corpuscular Hemoglobin Concentration, RDW Red Cell Distribution Width, PLT Platelets, MPV Mean Platelet Volume, NEU Neutrophils (Sometimes labeled GR or Grans.), LYM Lymphocytes, MONO Monocytes, EOS Eosinophils, LUC Large unstained cell (peroxidase negative), BASO Basophils