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. 2020 Mar 19;18:53. doi: 10.1186/s12951-020-00600-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cell viability of HEI-OC1 pretreated with ATX and ATX-LPN on CDDP-induced cell injury. a Cell viability of HEI-OC1 cells treated with a series of concentrations of CDDP (0, 10, 30, 60, 100 μM) for 24 h. b Cell viability of HEI-OC1 cells 60 μM CDDP at different incubation times (1, 3, 6, 12, and 24 h). c Cell viability of HEI-OC1 cells treated with drug free LPN. d Cell viability of HEI-OC1 cells pretreatment with ATX or ATX-LPN (1, 5, 10, 15 μg/ml) followed by 60 μM CDDP treatment for 24 h. **p < 0.01; ***p < 0.001 as compared with control. ^###p < 0.001 as compared with ATX