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. 2020 Mar 18;13:22. doi: 10.1186/s13045-020-00854-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Development and characterization of the m⁶A/5mC epigenetic module eigengenes (EMEs). a Module membership-based hub m⁶A and 5mC regulators across 33 cancer types. The lower panel shows the number of hub m⁶A and 5mC regulators in each cancer type. b Correlations between the number of hub m⁶A regulators and the number of hub 5mC regulators. The Pearson correlation coefficients (R) are shown. c Gene set enrichment analysis (GSEA) results (normalized enrichment scores [NES] and q values) regarding the hallmark oncogenic pathways for EME^high versus EME^low subgroups across 33 cancer types. Enrichment score terms with an FDR < 0.05 are shown. d Heatmap showing the Pearson correlation coefficients between the EMEs and immuno-stromal signatures across 30 cancer types. Diffuse large B cell lymphoma (DLBC), acute myeloid leukemia (LAML), and thymoma (THYM) were excluded, as they mainly consist of immune cells

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