Table 3.
Pulmonary function test at first SAC visit compared to GIA
| Severe Asthma Clinic children | GIA children with asthma | GIA children without asthma | ||
|---|---|---|---|---|
|
n = 23 Mean/median (SD/min-max) |
n = 7 Mean/median (SD/min-max) |
n = 13 Mean/median (SD/min-max) |
p value | |
| FVC litres pre BD | 2.6/2.6 (0.7/1.3–4.0) | 2.4/2.4 (0.5/1.9–3.4) | 2.3/2.4 (0.4/1.6–3.1) | 0.546 |
| FVC % pre BD | 97.7/98 (14.9/64–127) | 93.5/94.5 (11.6/75.2–111)$ | 108.5/109.2 (10.5/84.1–124)$ | 0.019 |
| FEV1 litres pre BD | 1.8/1.9 (0.6/1.1–3.3) | 2.1/2.0 (0.3/1.7–2.6) | 1.9/2.1 (0.3/1.2–2.6) | 0.300 |
| FEV1% pre BD | 78.4/81 (17.7/40–112) * | 94.9/95 (5.8/86–103) | 102.7/104.8 (12.13/72–121)* | 0.0001 |
| Abnormal FEV1% pre BD# | 11(48) | 0 | 1(8) | 0.007 |
| FEV1/FVC litres pre BD | 70.3/69.4 (9.5/47.7–88.2)! | 88.0/84.1 (7.9/78.1–98.4)! | 121.3/119.4 (8.1/110.3–135.2)! | < 0.0001 |
| FVC litres post BD | 2.8/2.7 (0.8/1.3–4.1) | 2.4/2.5 (0.5/1.9–3.3) | 2.4/2.4 (0.4/1.7–3.2) | 0.189 |
| FVC % post BD | 102.3/104 (13.22/75–124) | 95.9/98.1 (9.8/82–109)$ | 109.9/110.2 (8.7/90–122.3)$ | 0.011 |
| FEV1 litres post BD | 2.0/2.1 (0.6/1.1–3.5) | 2.2/2.2 (0.3/1.8–2.7) | 2.1/2.2 (0.4/1.3–2.8) | 0.458 |
| FEV1% post BD | 85.7/88 (16.7/47–117)* | 99.2/99.8 (4.8/92–106) | 109.6/112 (12.2/78.1–129.2)* | < 0.0001 |
| FEV1/FVC litres post BD | 73.7/73.7 (9.6/55.7–92.3)! | 89.3/90.2 (5.5/79.9–96.1)! | 87.1/89.6 (5.1/75.9–94.4)! | < 0.0001 |
| BDR % | 11/7 [11.3/(−2)-45] | 4/6 [4.3/(−1.2)-10] | 7/7 (3.7/0–13) | 0.187 |
| BDR ≥12%# | 6(26) | 0 | 1(8) | 0.158 |
| TLC% | 115/111 (21/88–184) | – | – | – |
| TLC litres | 4/4 (1/3–6) | – | – | – |
| RV/TLC % | 157/152 (42/92–254) | – | – | – |
| Abnormal RV/TLC%# | 13(57) | – | – | – |
| n = 14 | n = 7 | n = 11 | ||
| LCI | 10.5/10.7 (2.3/7.1–13.9)! | 7.6/7.4 (1.2/6.3–9.9)! | 7.3/7.3 (1.0/5.4–9.1)! | 0.003 |
| Abnormal LCI (%)@ | 11(79) | 1(14) | 3(27) | 0.002 |
| FRC/body weight (mL/kg) | 47/46 (15/23–76) | 36/35 (10/20–50) | 44/42 (14/21–72) | 0.211 |
| FeNO (ppb)** | 31.7/15 (31/6–90) | 31/20 (25/12–74) | 24/21 (19/7–51) | 0.861 |
| Abnormal FeNO# | 8(38) | 2(40)# | 2(40)# | 0.934 |
@LCI in a health cohort is ≤ 8 [20, 22, 23]
#Values presented as n (% of total); ** FeNO n = 21;Only 5 participants from each GIA group had valid FeNO results.*Significant between SAC and GIA without asthma; $Significant between both GIA groups
!Significant between SAC and GIA with asthma, and also between SAC and GIA without asthma