Table 5.
Pulmonary function test first and follow-up for SAC patients stratified for intervention
| Intervention including biological treatment | Intervention including biological treatment | Intervention excluding biological treatment | Intervention excluding biological treatment | |||
|---|---|---|---|---|---|---|
| n = 7 Mean/median (SD/min-max) |
n = 7 Mean/median (SD/min-max) |
p value | n = 9 Mean/median (SD/min-max) |
n = 9 Mean/median (SD/min-max) |
p value | |
| FVC litres pre BD | 2.6/2.1 (0.6/1.8–3.7) | 3.9/3.5 (1.5/2.5–6.7) | 0.0255 | 2.5/2.6 (0.6/1.6–3.5) | 3.5/3.4 (1.2/1.4–5.3) | 0.004 |
| FVC % pre BD | 88.1/86 (16.5/64–109) | 106.1/110 (8.1/95–114) | 0.0318 | 95.3/96 (9.5/81–108) | 96.2/93 (9.7/81–110) | 0.809 |
| FEV1 litres pre BD | 1.7/1.8 (0.5/1.1–2.5) | 2.8/2.4 (1.2/1.7–4.9) | 0.0258 | 1.7/1.7 (0.4/1.1–2.4) | 2.7/2.8 (0.7/1.2–3.4) | 0.0005 |
| FEV1% pre BD | 68.0/71 (19.3/40–91) | 82.4/78 (15.5/59–107) | 0.0787 | 71.2/72 (10.1/57–84) | 85.4/87 (6.1/73/92) | 0.004 |
| Abnormal FEV1% pre BD | 5(71) | 4(57) | 0.5770 | 6(67) | 1(11) | 0.016 |
| FEV1/FVC litres pre BD | 65.7/66.8 (8.8/47.6–73.4) | 71.8/69.4 (4.8/67.6–80) | 0.1240 | 67.9/67.7 (9.1/57.6–88.2) | 78.0/77.6 (9.8/64.7–95.3) | 0.012 |
| FVC litres post BD | 2.8/2.8 (0.6/2.1–3.9) | 3.9/3.6 (1.5/2.6–6.8) | 0.0295 | 2.6/2.7 (0.6/1.6–3.7) | 3.7/3.4 (1.2/1.5–5.5) | 0.004 |
| FVC % post BD | 94/91 (14.4/75–113) | 108.3/109 (6.5/97/116) | 0.0282 | 100.7/102 (9.7/85–117) | 99.8/102 (10.2/84–114) | 0.837 |
| FEV1 litres post BD | 1.9/1.9 (0.5/1.2–2.7) | 2.9/2.7 (1.4/1.6–5.6) | 0.0631 | 1.8/1.7 (0.4/1.2–2.5) | 2.8/2.9 (0.7/1.3–4.1) | 0.0007 |
| FEV1% post BD | 75.1/79 (17.2/47–94) | 90/85 (18.4/66–118) | 0.0952 | 81.1/77 (10.7/89–98) | 89.8/93 (8.5/73–98) | 0.009 |
| FEV1/FVC litres post BD | 68.7/71.4 (8.1/55.7–79.6) | 72.2/74.3 (9.9/54–82.6) | 0.5572 | 72.5/72.9 (10.1/58.9–92.3) | 79.1/75.7 (10.6/65.1–98.3) | 0.037 |
| BDR % | 13/6 (16/3–45) | 13/12 (7/3–23) | > 0.9999 | 9/9 [9/(−4)-29] | 5/4 [6/(−4)-18] | 0.243 |
| TLC% | 117/110 (31/88–184) | 104/100 (1/92–101) | 0.3830 | 117/114 (18/90–147) | 106/105 (15/86–140) | 0.096 |
| TLC litres | 4/4 (1/3–6) | 19/5 (36/3–101) | 0.3308 | 4/4 (1/2–6) | 5/5 (2/2–7) | 0.009 |
| RV/TLC % | 167/166 (53/112–254) | 131/135 (42/77–199) | 0.0579 | 175/181 (28/125–222) | 132/127 (25/98–184) | < 0.0001 |
| Abnormal RV/TLC % | 4(57) | 3(43) | 0.5930 | 8(89) | 3(33) | 0.016 |
| ACT scorea | 14/14 (6/8–21) | 19/20 (6/12–24) | 0.2486 | 15/15 (5/8–25) | 19/19 (5/13–25) | 0.022 |
| Percentage of ACT score ≤ 19 a | 4(67) | 3(50) | 0.6963 | 7(78) | 5(56) | 0.317 |
| n = 5 | n = 5 | n = 2 | n = 2 | |||
| LCI | 11.1/10.9 (2/8.6–13.6) | 9.6/8.3 (2.4/7.2–12.8) | 0.3435 | 12.4/12.4 (2.7/10.5–14.3) | 8.5/8.5 (0.3/8.3–8.7) | – |
| Abnormal LCI (%) | 5(100) | 4(80) | 0.2918 | – | – | – |
| FRC/body weight (mL/kg) | 50/47 (11/38–62) | 56/48 (18/34–79) | 0.2347 | 49/49 (10/41–58) | 60/60 (10/50–70) | – |
| FeNO (ppb)a | 32/25 (29/8–87) | 42/49 (29/6–76) | 0.4576 | 27/16 (24/6–60) | 31/14 (37/4–100) | 0.728 |
| Abnormal FeNOa | 3(50) | 4(67) | 0.5582 | 2(33) | 2(33) | – |
aACT score n = 6; FeNO n = 6