TABLE 3.

Summary of recommendation 3.

Phase	Duration	Treatment
Induction	2 weeks	Preferred regimen: 1 week of amphotericin B deoxycholate (1 mg/kg/day) and flucytosine (100 mg/kg/day divided into four doses per day), followed by 1 week of fluconazole (1200 mg daily for adults; 12 mg/kg/day for children and adolescents up to a maximum of 800 mg daily) Alternative options 2 weeks of fluconazole (1200 mg daily for adults; 12 mg/kg/day for children and adolescents) and flucytosine (100 mg/kg/day divided into four doses per day) Preferred option if flucytosine is unavailable: 2 weeks of amphotericin B deoxycholate (1 mg/kg/day) and fluconazole (1200 mg daily for adults, 12 mg/kg/day for children and adolescents) If liposomal amphotericin B is available for patients with renal dysfunction: 1 week of liposomal amphotericin B (3 mg/kg/day – 4 mg/kg/day) and flucytosine (100 mg/kg/day divided into four doses per day), followed by 1 week of fluconazole (both fluconazole and flucytosine doses adjusted for renal impairment)
Consolidation	8 weeks	Fluconazole (800 mg daily for adults; 12 mg/kg/day for children and adolescents up to a maximum of 800 mg daily)
Maintenance	Continue for at least 12 months until a single CD4 count > 200 cells/µL and a suppressed HIV viral load	Fluconazole (200 mg daily for adults; 6 mg/kg/day for children and adolescents up to a maximum of 200 mg daily)