TABLE 9.

Summary of recommendation 5.

Scenario	Sub-recommendations
Following a first or relapse episode of CM	Start ART 4–6 weeks after diagnosis of CM. The panel strongly advises that ART must not be delayed beyond 6 weeks after diagnosis, and most members of the panel advise that clinicians should aim to start exactly 4 weeks after diagnosis of CM No adjustment in first-line ART regimen is required for patients who are ART-naïve (unless renal dysfunction precludes the use of tenofovir)
Following a new diagnosis of cryptococcal antigenaemia	If CM has been excluded, start ART immediately Asymptomatic CrAg-positive patients who decline consent for LP or for whom LP is contraindicated should start on ART after at least 2 weeks of antifungal treatment

CM, cryptococcal meningitis; LP, lumbar puncture; ART, antiretroviral treatment.