In health economic decision making, uncertainty information is currently not reported systematically, which leaves decision makers with the cognitively challenging task of translating pieces of qualitative and quantitative uncertainty information into an overall assessment of uncertainty and risk.

When considering uncertainty in health economic models, undue emphasis is placed on imprecision issues, which may lead to misrepresentation of uncertainty and ultimately of risk.

The TRansparent Uncertainty ASsessmenT (TRUST) tool enables the systematic identification, assessment, and reporting of uncertainties in health economic models, which may contribute to more informed and transparent decision making in the face of uncertainty.