Table 2.

Specific diagnoses prompting hospital admissions, outpatient clinic visits or emergency department visits

Diagnosis	ILA (%)	No ILA (%)	HR	95% CI	Adjusted p-value
Respiratory	116 (34.9)	361 (21.8)	1.6	1.3–2.0	<  0.001
COPD	55 (16.6)	159 (9.6)	1.7	1.2–2.3	0.01
Pneumonia	56 (16.9)	126 (7.6)	2.0	1.4–2.7	<  0.001
Asthma	4 (1.2)	47 (2.8)	0.4	0.2–1.2	0.15
Pleural empyema or lung abscess	5 (1.5)	3 (0.2)	6.6	1.5–28.8	0.03
Interstitial lung disease	8 (2.4)	8 (0.5)	4.9	1.8–13.3	0.008
Respiratory failure	25 (7.5)	61 (3.7)	1.8	1.1–3.0	0.03
Malignant neoplasm	93 (28.0)	317 (19.1)	1.4	1.1–1.8	0.02
Lung cancer	39 (11.7)	71 (4.3)	2.7	1.8–4.0	<  0.001
Non-pulmonary cancer	67 (20.2)	266 (16.0)	1.2	0.9–1.6	0.30
Cardiovascular	157 (47.3)	652 (39.3)	1.2	1.0–1.5	0.09
Heart failure	19 (5.7)	47 (2.8)	1.7	1.0–3.0	0.19
Pulmonary embolism	8 (2.4)	22 (1.3)	1.9	0.8–4.3	0.17
Atrial fibrillation/atrial flutter	27 (8.1)	95 (5.7)	1.3	0.8–2.0	0.34
Ischemic heart disease	50 (15.1)	174 (10.5)	1.4	1.0–2.0	0.07
Cerebral infarction	18 (5.4)	59 (3.6)	1.4	0.8–2.3	0.34
Peripheral vascular disease	21 (6.3)	50 (3.0)	2.0	1.2–3.4	0.04
Gastrointestinal	125 (37.7)	489 (29.5)	1.3	1.1–1.6	0.02
GORD, gastritis or ulcer disease	25 (7.5)	95 (5.7)	1.3	0.8–2.1	0.30
Functional intestinal disorders	28(8.4)	66(4.0)	2.2	1.4–3.4	0.006
Musculoskeletal system and connective tissue	140 (42.2)	739 (44.6)	1.0	0.8–1.2	0.89
Inflammatory polyarthropathies	8 (2.4)	57 (3.4)	0.7	0.3–1.5	0.40

ILA interstitial lung abnormalities, HR hazard ratio, COPD chronic obstructive pulmonary disease, GORD gastro-oesophageal reflux disease

Number of participants with ILA compared with participants without ILA for receiving one of several specific diagnoses of interest at a hospital admission, outpatient clinic visits or emergency department visit. Cox regression analysis is adjusted for age, sex, BMI and pack-years. P-values are adjusted for multiple comparisons by the Benjamini-Hochberg method