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. 2020 Mar 12;8:164. doi: 10.3389/fbioe.2020.00164

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Crown Copyright © 2020 APHA. Konold, Spiropoulos, Thorne, Phelan, Fothergill, Rajanayagam, Floyd, Vidana, Charnley, Coates and Simmons

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical examination of brain and lymphoid tissue from selected goats. Obex (A) and medial retropharyngeal LN (B) from clinical suspect goat 2135, positive on brain by ELISA and WB; obex (C) from goat 2146 with inconclusive signs with regard to scrapie, negative on brain by ELISA and WB and pre-scapular LN (D) from clinical suspect goat 2169, negative by all tests on brain, PrP^Sc detected in pre-scapular LN only. Note the comparatively sparser PrP^Sc accumulation in the obex in C (immunolabeling visible in only one neuron) compared to A. Immmunolabeling is restricted to tingible body macrophages in the pre-scapular LN in D whereas macrophages and follicular dendritic cells are both immunolabeled in B.