TABLE 1.
Goat ID | Breed | Age [m] | PRNP Genotype | ELISA (obex) | IHC obex | WB (obex or caudal medulla) | IHC (lymphoid tissue) | Clinical status |
2113 | TO | 60 | II142 PP240 | P | P | P | P | SuspectI |
2135 | SA | 36 | II142 PP240 | P | P | P | P | Suspect |
2073 | TO | 60 | II142 SP240 | P | P | P** | P | Inconclusive |
2146 | SA | 24 | II142 PP240 | N | P* | N** | P | Inconclusive |
2165 | AL | 24 | II142 SP240 | N | P* | Inconclusive | P | No evidence |
2176 | TO | 24 | II142 SS240 | N | P | P | P | No evidence |
2078 | AL | 72 | II142 PP240 | N | P | P | P | No evidence |
2117 | SA | 24 | IM142 PP240 | N | N | P | P | No evidence |
2191 | TO | 60 | II142 SP240 | N | N | N | P | Suspect |
2169 | SA | 60 | IM142 PP240 | N | N | N | P | SuspectII |
2179 | AL | 24 | II142 SP240 | N | N | N | P | Inconclusive |
2112 | SA | 60 | II142 PP240 | N | N | N | P | Inconclusive |
2166 | TO | 24 | IM142 SP240 | N | N | N | P | No evidence |
2201 | TO | 60 | IM142 PP240 | N | N | N | P | No evidence |
2126 | SA | 60 | II142 PP240 | N | N | N | P | No evidence |
2182 | SA | 24 | II142 PP240 | N | N | N | P | No evidence |
2143 | TO | 60 | II142 SP240 | N | N | N | P | No evidence |
2155 | TO | 24 | II142 SP240 | N | N | N | P | No evidence |
AL = Alpine, SA = Saanen, TO = Toggenburg. All goats were GG127, RR211, and QQ222. *Minimal immunolabeling; **caudal medulla was tested; P = positive, N = negative; one WB result was classified as inconclusive because of an extremely weak band at approximately 27 kDa (the PrPres region), Ivideo clip “classical scrapie in goats” of this animal available to view at https://www.youtube.com/watch?v=Kkhak9yJ3H0 (Konold and Vallino Costassa, 2018); IIsee Supplementary Video File S1.